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    Tmem232 transmembrane protein 232 [ Mus musculus (house mouse) ]

    Gene ID: 381107, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmem232provided by MGI
    Official Full Name
    transmembrane protein 232provided by MGI
    Primary source
    MGI:MGI:2685786
    See related
    Ensembl:ENSMUSG00000045036 AllianceGenome:MGI:2685786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm940; Tes13-L; Tes13-S; E130009J12Rik
    Summary
    Involved in flagellated sperm motility and spermatogenesis. Acts upstream of or within maintenance of protein complex location and spermatid cytoplasm removal during spermiation of flagellated sperm. Is active in outer dense fiber. Orthologous to human TMEM232 (transmembrane protein 232). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 15.4) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tmem232 in Genome Data Viewer
    Location:
    17 E1.1; 17 34.9 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (65562994..65848080, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65255999..65541082, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43005 Neighboring gene predicted gene, 49865 Neighboring gene STARR-seq mESC enhancer starr_43006 Neighboring gene enolase 1, alpha non-neuron pseudogene Neighboring gene STARR-seq mESC enhancer starr_43009 Neighboring gene STARR-seq mESC enhancer starr_43010 Neighboring gene hypoxanthine guanine phosphoribosyl transferase pseudogene Neighboring gene predicted gene 9288 Neighboring gene STARR-seq mESC enhancer starr_43012 Neighboring gene mitochondrial ribosomal protein S10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43013 Neighboring gene predicted gene, 53984 Neighboring gene ribosomal protein L18 pseudogene Neighboring gene predicted gene, 35400 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in outer dense fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in outer dense fiber IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    transmembrane protein 232
    Names
    testis-specific protein 13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008973.2NP_001008973.2  transmembrane protein 232 isoform a

      See identical proteins and their annotated locations for NP_001008973.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AF338469, BB538070, BB618060, CAAA01027226, DV662151
      Consensus CDS
      CCDS28940.1
      UniProtKB/Swiss-Prot
      B2RX35, B7ZWG2, Q5K6N0, Q5K6N1
      Related
      ENSMUSP00000083927.4, ENSMUST00000086722.10
      Conserved Domains (1) summary
      pfam15877
      Location:40488
      TMEM232; Transmembrane protein family 232
    2. NM_001289485.1NP_001276414.1  transmembrane protein 232 isoform a

      See identical proteins and their annotated locations for NP_001276414.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 encode the same protein.
      Source sequence(s)
      BB618060, BC150885, BX638107, CT030729
      Consensus CDS
      CCDS28940.1
      UniProtKB/Swiss-Prot
      B2RX35, B7ZWG2, Q5K6N0, Q5K6N1
      Related
      ENSMUSP00000055652.7, ENSMUST00000062161.7
      Conserved Domains (1) summary
      pfam15877
      Location:40488
      TMEM232; Transmembrane protein family 232
    3. NM_001289486.1NP_001276415.1  transmembrane protein 232 isoform b

      See identical proteins and their annotated locations for NP_001276415.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. It encodes a shorter isoform (b), compared to isoform a.
      Source sequence(s)
      BB618060, BC172032, BX638107
      Consensus CDS
      CCDS89134.1
      UniProtKB/Swiss-Prot
      Q5K6N0
      Related
      ENSMUSP00000156833.2, ENSMUST00000233117.2
      Conserved Domains (1) summary
      pfam15877
      Location:40487
      TMEM232; Transmembrane protein family 232
    4. NM_001360185.1NP_001347114.1  transmembrane protein 232 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC154457, AC154821, CT030729
      Consensus CDS
      CCDS89135.1
      Related
      ENSMUSP00000156513.2, ENSMUST00000233738.2
      Conserved Domains (2) summary
      pfam15877
      Location:7454
      TMEM232; Transmembrane protein family 232
      cl25602
      Location:551626
      DUF3552; Domain of unknown function (DUF3552)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      65562994..65848080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524493.4XP_006524556.1  transmembrane protein 232 isoform X2

      UniProtKB/TrEMBL
      A0A3B2W4C3
      Related
      ENSMUSP00000156859.2, ENSMUST00000233328.2
      Conserved Domains (2) summary
      pfam15877
      Location:1372
      TMEM232; Transmembrane protein family 232
      pfam18654
      Location:483552
      LegC3_N; LegC3 N-terminal coiled-coil domain
    2. XM_006524492.4XP_006524555.1  transmembrane protein 232 isoform X1

      Conserved Domains (2) summary
      pfam15877
      Location:40402
      TMEM232; Transmembrane protein family 232
      pfam18654
      Location:513582
      LegC3_N; LegC3 N-terminal coiled-coil domain
    3. XM_030249871.1XP_030105731.1  transmembrane protein 232 isoform X3

      Conserved Domains (2) summary
      pfam15877
      Location:7368
      TMEM232; Transmembrane protein family 232
      pfam18654
      Location:479548
      LegC3_N; LegC3 N-terminal coiled-coil domain

    RNA

    1. XR_004939547.1 RNA Sequence