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    Foxp4 forkhead box P4 [ Mus musculus (house mouse) ]

    Gene ID: 74123, updated on 3-Dec-2024

    Summary

    Official Symbol
    Foxp4provided by MGI
    Official Full Name
    forkhead box P4provided by MGI
    Primary source
    MGI:MGI:1921373
    See related
    Ensembl:ENSMUSG00000023991 AllianceGenome:MGI:1921373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mFKHLA; 1200010K03Rik; 2310007G05Rik
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic foregut morphogenesis; lung secretory cell differentiation; and negative regulation of lung goblet cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; hindlimb digit mesenchyme; and skeleton. Orthologous to human FOXP4 (forkhead box P4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in stomach adult (RPKM 50.9), colon adult (RPKM 45.3) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Foxp4 in Genome Data Viewer
    Location:
    17 C; 17 23.99 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48178058..48235401, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47867133..47924632, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25201 Neighboring gene nuclear encoded rRNA 5S 28 Neighboring gene STARR-seq mESC enhancer starr_42731 Neighboring gene STARR-seq mESC enhancer starr_42732 Neighboring gene STARR-seq mESC enhancer starr_42734 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48037747-48037856 Neighboring gene STARR-positive B cell enhancer ABC_E8679 Neighboring gene STARR-positive B cell enhancer ABC_E9170 Neighboring gene macrophage migration inhibitory factor, pseudogene 8 Neighboring gene predicted gene, 29938

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    forkhead box protein P4
    Names
    fork head-related protein like A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110824.2NP_001104294.1  forkhead box protein P4 isoform 1

      See identical proteins and their annotated locations for NP_001104294.1

      Status: VALIDATED

      Source sequence(s)
      AC113536, AC164306
      Consensus CDS
      CCDS50137.1
      UniProtKB/TrEMBL
      A0A0R4J161, D3Z726
      Related
      ENSMUSP00000094916.3, ENSMUST00000097311.9
      Conserved Domains (3) summary
      smart00339
      Location:472544
      FH; FORKHEAD
      COG5025
      Location:370565
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:309376
      FOXP-CC; FOXP coiled-coil domain
    2. NM_001110825.2NP_001104295.1  forkhead box protein P4 isoform 2

      See identical proteins and their annotated locations for NP_001104295.1

      Status: VALIDATED

      Source sequence(s)
      AC113536, AC164306
      Consensus CDS
      CCDS50136.1
      UniProtKB/TrEMBL
      A0A0R4J1I5, D3Z726
      Related
      ENSMUSP00000108887.2, ENSMUST00000113262.2
      Conserved Domains (2) summary
      pfam00250
      Location:460539
      Forkhead; Forkhead domain
      pfam16159
      Location:309376
      FOXP-CC; FOXP coiled-coil domain
    3. NM_001403969.1NP_001390898.1  forkhead box protein P4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC113536, AC164306
      UniProtKB/TrEMBL
      D3Z726
    4. NM_001403970.1NP_001390899.1  forkhead box protein P4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113536, AC164306
      UniProtKB/TrEMBL
      D3Z726
    5. NM_028767.3NP_083043.2  forkhead box protein P4 isoform 3

      See identical proteins and their annotated locations for NP_083043.2

      Status: VALIDATED

      Source sequence(s)
      AC113536, AC164306
      Consensus CDS
      CCDS50135.1
      UniProtKB/TrEMBL
      D3Z726
      Related
      ENSMUSP00000108890.2, ENSMUST00000113265.8
      Conserved Domains (2) summary
      pfam00250
      Location:459538
      Forkhead; Forkhead domain
      pfam16159
      Location:308375
      FOXP-CC; FOXP coiled-coil domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48178058..48235401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317686.2XP_017173175.1  forkhead box protein P4 isoform X1

      UniProtKB/TrEMBL
      D3Z726
      Conserved Domains (3) summary
      smart00339
      Location:479551
      FH; FORKHEAD
      COG5025
      Location:375572
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:309376
      FOXP-CC; FOXP coiled-coil domain
    2. XM_030250107.1XP_030105967.1  forkhead box protein P4 isoform X3

      UniProtKB/TrEMBL
      A0A0R4J161, D3Z726
      Conserved Domains (3) summary
      smart00339
      Location:472544
      FH; FORKHEAD
      COG5025
      Location:370565
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:309376
      FOXP-CC; FOXP coiled-coil domain
    3. XM_017317687.3XP_017173176.1  forkhead box protein P4 isoform X1

      UniProtKB/TrEMBL
      D3Z726
      Conserved Domains (3) summary
      smart00339
      Location:479551
      FH; FORKHEAD
      COG5025
      Location:375572
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam16159
      Location:309376
      FOXP-CC; FOXP coiled-coil domain