Ly6g6c lymphocyte antigen 6 family member G6C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ly6g6cprovided by MGI
Official Full Name: lymphocyte antigen 6 family member G6Cprovided by MGI
Primary source: MGI:MGI:2148930
See related: Ensembl:ENSMUSG00000092586 AllianceGenome:MGI:2148930
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G6c; NG24; 1110003M04Rik
Summary: Enables identical protein binding activity. Acts upstream of or within response to bacterium. Part of protein-containing complex. Colocalizes with external side of plasma membrane. Is expressed in several structures, including brain; liver; lung; metanephros; and spleen. Orthologous to human LY6G6C (lymphocyte antigen 6 family member G6C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in stomach adult (RPKM 153.4), testis adult (RPKM 51.0) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.59 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (35286301..35289024)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35067325..35070048)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

General gene information

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Markers

AU016360 (e-PCR)
- UniSTS:181001

NoName (e-PCR)
- UniSTS:493105

Ly6g6c (e-PCR), detects polymorphism
- UniSTS:256870

Ly6g6c (e-PCR), detects polymorphism
- UniSTS:256871

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with external side of plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lymphocyte antigen 6 complex locus protein G6c

Names: lymphocyte antigen 6 complex G6C; lymphocyte antigen 6 complex, locus G6C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023463.3 → NP_075952.1 lymphocyte antigen 6 complex locus protein G6c precursor

See identical proteins and their annotated locations for NP_075952.1

Status: VALIDATED

Source sequence(s)

AA061950, AK003375

Consensus CDS

CCDS28677.1

UniProtKB/Swiss-Prot

Q9Z1Q4

UniProtKB/TrEMBL

G3UYS0, Q545T2

Related

ENSMUSP00000133510.2, ENSMUST00000173478.2

Conserved Domains (1) summary

cl10471
Location:22 → 103

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...