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    Tm9sf1 transmembrane 9 superfamily member 1 [ Mus musculus (house mouse) ]

    Gene ID: 74140, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tm9sf1provided by MGI
    Official Full Name
    transmembrane 9 superfamily member 1provided by MGI
    Primary source
    MGI:MGI:1921390
    See related
    Ensembl:ENSMUSG00000002320 AllianceGenome:MGI:1921390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MP70; 1200014D02Rik
    Summary
    Predicted to be involved in protein localization to membrane. Predicted to be located in autophagosome membrane; cytoplasmic vesicle; and lysosomal membrane. Predicted to be active in membrane. Is expressed in several structures, including brain; eye; liver; muscle tissue; and spleen. Orthologous to human TM9SF1 (transmembrane 9 superfamily member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 42.3), adrenal adult (RPKM 39.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tm9sf1 in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55873422..55881263, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55635965..55643806, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene REC8 meiotic recombination protein Neighboring gene importin 4 Neighboring gene testis-specific serine kinase 4 Neighboring gene magnesium-dependent phosphatase 1 Neighboring gene neural precursor cell expressed, developmentally down-regulated gene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of the expression patterns of TM9SF family members in mice. Zhao R, et al. Gene Expr Patterns, 2024 Jun. PMID 38719197
    2. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Hald J, et al. Diabetologia, 2012 Jan. PMID 21947380
    3. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article
    4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane 9 superfamily member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360063.1 → NP_001346992.1  transmembrane 9 superfamily member 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AK004754, BB610966, BE996262, BY767651
      Consensus CDS
      CCDS27122.1
      UniProtKB/Swiss-Prot
      Q3U7S4, Q8VD27, Q922J5, Q9DBU0, Q9ET29
      UniProtKB/TrEMBL
      D3Z6X7
      Related
      ENSMUSP00000002391.9, ENSMUST00000002391.15
      Conserved Domains (1) summary
      pfam02990
      Location:59 → 562
      EMP70; Endomembrane protein 70

    2. NM_028780.3 → NP_083056.2  transmembrane 9 superfamily member 1 precursor

      See identical proteins and their annotated locations for NP_083056.2

      Status: VALIDATED

      Source sequence(s)
      AK004754
      Consensus CDS
      CCDS27122.1
      UniProtKB/Swiss-Prot
      Q3U7S4, Q8VD27, Q922J5, Q9DBU0, Q9ET29
      UniProtKB/TrEMBL
      D3Z6X7
      Related
      ENSMUSP00000113782.2, ENSMUST00000122358.8
      Conserved Domains (1) summary
      pfam02990
      Location:59 → 562
      EMP70; Endomembrane protein 70

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55873422..55881263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248054.2 → XP_030103914.1  transmembrane 9 superfamily member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U7S4, Q8VD27, Q922J5, Q9DBU0, Q9ET29
      UniProtKB/TrEMBL
      D3Z6X7
      Conserved Domains (1) summary
      pfam02990
      Location:59 → 562
      EMP70; Endomembrane protein 70

    2. XM_006519616.3 → XP_006519679.1  transmembrane 9 superfamily member 1 isoform X2

      UniProtKB/TrEMBL
      D3YWH4
      Conserved Domains (1) summary
      pfam02990
      Location:59 → 406
      EMP70; Endomembrane protein 70

    3. XM_030248052.2 → XP_030103912.1  transmembrane 9 superfamily member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U7S4, Q8VD27, Q922J5, Q9DBU0, Q9ET29
      UniProtKB/TrEMBL
      D3Z6X7
      Related
      ENSMUSP00000112893.2, ENSMUST00000120041.8
      Conserved Domains (1) summary
      pfam02990
      Location:59 → 562
      EMP70; Endomembrane protein 70

    4. XM_030248053.1 → XP_030103913.1  transmembrane 9 superfamily member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U7S4, Q8VD27, Q922J5, Q9DBU0, Q9ET29
      UniProtKB/TrEMBL
      D3Z6X7
      Related
      ENSMUSP00000112764.2, ENSMUST00000121791.8
      Conserved Domains (1) summary
      pfam02990
      Location:59 → 562
      EMP70; Endomembrane protein 70

    5. XM_030248051.1 → XP_030103911.1  transmembrane 9 superfamily member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U7S4, Q8VD27, Q922J5, Q9DBU0, Q9ET29
      UniProtKB/TrEMBL
      D3Z6X7
      Conserved Domains (1) summary
      pfam02990
      Location:59 → 562
      EMP70; Endomembrane protein 70

    6. XM_006519617.4 → XP_006519680.1  transmembrane 9 superfamily member 1 isoform X4

      UniProtKB/TrEMBL
      D6RGM8
      Conserved Domains (1) summary
      pfam02990
      Location:59 → 386
      EMP70; Endomembrane protein 70

    7. XM_030248055.2 → XP_030103915.1  transmembrane 9 superfamily member 1 isoform X3

      UniProtKB/TrEMBL
      D6RGM8
      Conserved Domains (1) summary
      pfam02990
      Location:59 → 387
      EMP70; Endomembrane protein 70

    8. XM_030248056.2 → XP_030103916.1  transmembrane 9 superfamily member 1 isoform X4

      UniProtKB/TrEMBL
      D6RGM8
      Related
      ENSMUSP00000115403.2, ENSMUST00000149726.8
      Conserved Domains (1) summary
      pfam02990
      Location:59 → 386
      EMP70; Endomembrane protein 70

    9. XM_036158864.1 → XP_036014757.1  transmembrane 9 superfamily member 1 isoform X3

      UniProtKB/TrEMBL
      D6RGM8
      Conserved Domains (1) summary
      pfam02990
      Location:59 → 387
      EMP70; Endomembrane protein 70

    10. XM_036158865.1 → XP_036014758.1  transmembrane 9 superfamily member 1 isoform X3

      UniProtKB/TrEMBL
      D6RGM8
      Conserved Domains (1) summary
      pfam02990
      Location:59 → 387
      EMP70; Endomembrane protein 70
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBU0.2 GenPept UniProtKB/Swiss-Prot:Q9DBU0

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