Mhrt myosin heavy chain associated RNA transcript [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mhrtprovided by MGI
Official Full Name: myosin heavy chain associated RNA transcriptprovided by MGI
Primary source: MGI:MGI:3642848
See related: Ensembl:ENSMUSG00000097652 AllianceGenome:MGI:3642848
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Myheart; D830015G02Rik
Summary: This gene encodes a spliced long non-coding RNA that may act as a cardioprotective agent in the heart. This transcript is thought to regulate chromatin remodeling by acting as a decoy to the Brg1 chromatin repressor complex thus preventing it from binding to its genomic targets. Blocking the actions of Brg1 may be crucial in protecting the heart from pathological hypertrophy. [provided by RefSeq, Dec 2014]
Expression: Restricted expression toward heart adult (RPKM 492.2) See more
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Genomic context

Location:: 14 C3; 14 28.01 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55206215..55211915)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54968787..54974349)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA MHRT Promotes Cardiac Fibrosis via miR-3185 Pathway Following Myocardial Infarction.
Title: LncRNA MHRT Promotes Cardiac Fibrosis via miR-3185 Pathway Following Myocardial Infarction.
FTO overexpression inhibits apoptosis of hypoxia/reoxygenation-treated myocardial cells by regulating m6A modification of Mhrt.
Title: FTO overexpression inhibits apoptosis of hypoxia/reoxygenation-treated myocardial cells by regulating m6A modification of Mhrt.
LncRNA-Mhrt regulates cardiac hypertrophy by modulating the miR-145a-5p/KLF4/myocardin axis.
Title: LncRNA-Mhrt regulates cardiac hypertrophy by modulating the miR-145a-5p/KLF4/myocardin axis.
studies identify a cardioprotective lncRNA (Mhrt), define a new targeting mechanism for ATP-dependent chromatin-remodelling factors, and establish a new paradigm for lncRNA-chromatin interaction
Title: A long noncoding RNA protects the heart from pathological hypertrophy.

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General gene information

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Markers

Myhcb (e-PCR), detects polymorphism
- UniSTS:143962

Myh7 (e-PCR), detects polymorphism
- UniSTS:265580

Myh7 (e-PCR), detects polymorphism
- UniSTS:530876

MARC_5445-5446:996690391:1 (e-PCR)
- UniSTS:269515

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.