Zfyve16 zinc finger, FYVE domain containing 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfyve16provided by MGI
Official Full Name: zinc finger, FYVE domain containing 16provided by MGI
Primary source: MGI:MGI:2145181
See related: Ensembl:ENSMUSG00000021706 AllianceGenome:MGI:2145181
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0305; B130031L15; B130024H06Rik
Summary: Predicted to enable 1-phosphatidylinositol binding activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in endosomal transport and protein targeting to lysosome. Predicted to be located in cytosol and early endosome. Predicted to be active in early endosome membrane. Is expressed in central nervous system and genitourinary system. Orthologous to human ZFYVE16 (zinc finger FYVE-type containing 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 4.3), CNS E14 (RPKM 3.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C3; 13 47.72 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (92624257..92667318, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (92487749..92530810, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The proportion of T cells in the peripheral blood of Zfyve16(KO) mice increases compared with that in wild-type mice. B cell proliferation is inhibited in Zfyve16(KO) mice. The proliferation potential of Zfyve16(KO) B-lymphoid cells also significantly decreases in vitro. Zfyve16 inhibits the proliferation of T cells, possibly through the TGF-beta signaling, but upregulates the proliferation of B-lymphoid cells.
Title: Zfyve16 regulates the proliferation of B-lymphoid cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

41.MMHAP75FLF5.seq (e-PCR)
- UniSTS:124424

AI035632 (e-PCR)
- UniSTS:163541

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to lysosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to lysosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in early endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger FYVE domain-containing protein 16

Names: endofin; endosomal-associated FYVE domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173392.4 → NP_775568.1 zinc finger FYVE domain-containing protein 16

See identical proteins and their annotated locations for NP_775568.1

Status: PROVISIONAL

Source sequence(s)

AC154363

Consensus CDS

CCDS26682.1

UniProtKB/Swiss-Prot

Q80U44, Q8BRD2, Q8CG97

Related

ENSMUSP00000022217.9, ENSMUST00000022217.9

Conserved Domains (2) summary

cd15729
Location:726 → 792

FYVE_endofin; FYVE domain found in endofin and similar proteins

pfam11979
Location:1155 → 1503

DUF3480; Domain of unknown function (DUF3480)