Eef1akmt3 EEF1A lysine methyltransferase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eef1akmt3provided by MGI
Official Full Name: EEF1A lysine methyltransferase 3provided by MGI
Primary source: MGI:MGI:3645330
See related: Ensembl:ENSMUSG00000080115 AllianceGenome:MGI:3645330
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam119b; Gm16109; EG546486; Mettl21b
Summary: Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Predicted to be located in several cellular components, including centrosome; chromosome; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human EEF1AKMT3 (EEF1A lysine methyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 2.4), kidney adult (RPKM 2.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 74.5 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (126868654..126877883, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127032806..127042014, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-lysine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine N-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-lysine N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine methylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine methylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: EEF1A lysine methyltransferase 3

Names: Methyltransferase-like protein 21B; Protein-lysine methyltransferase METTL21B; family with sequence similarity 119, member B; methyltransferase like 21B

NP_001191965.1

EC 2.1.1.-

XP_017169241.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205036.1 → NP_001191965.1 EEF1A lysine methyltransferase 3

See identical proteins and their annotated locations for NP_001191965.1

Status: VALIDATED

Source sequence(s)

AC134329

Consensus CDS

CCDS56752.1

UniProtKB/Swiss-Prot

D3YWP0

Related

ENSMUSP00000111939.3, ENSMUST00000116231.4

Conserved Domains (1) summary

cl17173
Location:37 → 195

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

126868654..126877883 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313752.3 → XP_017169241.1 EEF1A lysine methyltransferase 3 isoform X1

Conserved Domains (1) summary

cl17173
Location:15 → 150

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...