U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Plk5 polo like kinase 5 [ Mus musculus (house mouse) ]

    Gene ID: 216166, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Plk5provided by MGI
    Official Full Name
    polo like kinase 5provided by MGI
    Primary source
    MGI:MGI:3026984
    See related
    Ensembl:ENSMUSG00000035486 AllianceGenome:MGI:3026984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330514A18Rik
    Summary
    Predicted to enable ATP binding activity and metal ion binding activity. Involved in several processes, including defense response to tumor cell; positive regulation of neuron projection development; and regulation of G1/S transition of mitotic cell cycle. Located in nucleolus. Is expressed in several structures, including central nervous system; eye; and ovary. Orthologous to human PLK5 (polo like kinase 5 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 19.2), cortex adult (RPKM 4.7) and 6 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Plk5 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80192293..80201323)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80356459..80365489)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51809 Neighboring gene receptor accessory protein 6 Neighboring gene ADAMTS-like 5 Neighboring gene mex3 RNA binding family member D Neighboring gene predicted gene, 30823 Neighboring gene methyl-CpG binding domain protein 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. de Cárcer G, et al. Mol Cell Biol, 2011 Mar. PMID 21245385, Free PMC Article
    2. The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus. Andrysik Z, et al. Nucleic Acids Res, 2010 May. PMID 20100802, Free PMC Article
    3. Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification. Petitpré C, et al. Nat Commun, 2022 Jul 5. PMID 35790771, Free PMC Article
    4. Genome-wide atlas of gene expression in the adult mouse brain. Lein ES, et al. Nature, 2007 Jan 11. PMID 17151600
    5. Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Pereira JD, et al. Proc Natl Acad Sci U S A, 2010 Sep 7. PMID 20798045, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC106082

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to tumor cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    inactive serine/threonine-protein kinase PLK5
    Names
    serine/threonine-protein kinase PLK5
    NP_001334053.1
    NP_898975.2
    XP_006513561.1
    XP_006513563.1
    XP_006513564.1
    XP_006513565.1
    XP_030100882.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347124.2 → NP_001334053.1  inactive serine/threonine-protein kinase PLK5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC152062
      Consensus CDS
      CCDS83729.1
      UniProtKB/Swiss-Prot
      Q0VGS4, Q4FZD7, Q8C096
      Related
      ENSMUSP00000100988.2, ENSMUST00000105351.2

    2. NM_001433556.1 → NP_001420485.1  inactive serine/threonine-protein kinase PLK5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC152062

    3. NM_001433557.1 → NP_001420486.1  inactive serine/threonine-protein kinase PLK5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC152062

    4. NM_001433558.1 → NP_001420487.1  inactive serine/threonine-protein kinase PLK5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC152062

    5. NM_001433559.1 → NP_001420488.1  inactive serine/threonine-protein kinase PLK5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC152062

    6. NM_183152.5 → NP_898975.2  inactive serine/threonine-protein kinase PLK5 isoform 1

      See identical proteins and their annotated locations for NP_898975.2

      Status: VALIDATED

      Source sequence(s)
      AC152062
      Consensus CDS
      CCDS35980.1
      UniProtKB/TrEMBL
      G3X967
      Related
      ENSMUSP00000044400.9, ENSMUST00000039836.15
      Conserved Domains (3) summary
      smart00220
      Location:27 → 283
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13118
      Location:414 → 501
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14099
      Location:25 → 283
      STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80192293..80201323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513498.1 → XP_006513561.1  inactive serine/threonine-protein kinase PLK5 isoform X1

      Conserved Domains (2) summary
      cd13118
      Location:423 → 510
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14099
      Location:25 → 292
      STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases

    2. XM_006513501.1 → XP_006513564.1  inactive serine/threonine-protein kinase PLK5 isoform X3

      Conserved Domains (2) summary
      cd13118
      Location:371 → 458
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cl21453
      Location:25 → 240
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006513500.5 → XP_006513563.1  inactive serine/threonine-protein kinase PLK5 isoform X2

      Conserved Domains (2) summary
      cd13118
      Location:377 → 464
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cl21453
      Location:1 → 246
      PKc_like; Protein Kinases, catalytic domain

    4. XM_030245022.2 → XP_030100882.1  inactive serine/threonine-protein kinase PLK5 isoform X5

      Conserved Domains (2) summary
      cd13118
      Location:325 → 412
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cl21453
      Location:1 → 194
      PKc_like; Protein Kinases, catalytic domain

    5. XM_006513502.4 → XP_006513565.1  inactive serine/threonine-protein kinase PLK5 isoform X4

      Conserved Domains (2) summary
      cd13118
      Location:356 → 443
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cl21453
      Location:5 → 225
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_380383.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4FZD7.1 GenPept UniProtKB/Swiss-Prot:Q4FZD7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools