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    Lgr6 leucine-rich repeat-containing G protein-coupled receptor 6 [ Mus musculus (house mouse) ]

    Gene ID: 329252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lgr6provided by MGI
    Official Full Name
    leucine-rich repeat-containing G protein-coupled receptor 6provided by MGI
    Primary source
    MGI:MGI:2441805
    See related
    Ensembl:ENSMUSG00000042793 AllianceGenome:MGI:2441805
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D830026M09; A530037C04Rik
    Summary
    Predicted to enable G protein-coupled receptor activity and protein-hormone receptor activity. Acts upstream of or within bone regeneration and cell population proliferation. Predicted to be located in vesicle. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including cochlea; jaw; renal cortex; skin; and telencephalon. Orthologous to human LGR6 (leucine rich repeat containing G protein-coupled receptor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 9.3), heart adult (RPKM 5.7) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lgr6 in Genome Data Viewer
    Location:
    1 E4; 1 58.24 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134911038..135033112, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134983300..135105374, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 12B Neighboring gene predicted gene, 51748 Neighboring gene STARR-positive B cell enhancer ABC_E1231 Neighboring gene microRNA 5104b Neighboring gene ubiquitin-conjugating enzyme E2T Neighboring gene STARR-seq mESC enhancer starr_02346 Neighboring gene STARR-seq mESC enhancer starr_02347 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:137029652-137029867 Neighboring gene STARR-positive B cell enhancer ABC_E9480 Neighboring gene protein tyrosine phosphatase receptor type V Neighboring gene protein tyrosine phosphatase, non-receptor type 7 Neighboring gene ADP-ribosylation factor-like 8A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cardiomyocyte LGR6 alleviates ferroptosis in diabetic cardiomyopathy via regulating mitochondrial biogenesis. Zhao M, et al. Metabolism, 2024 Oct. PMID 39038735
    2. Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma. Huang PY, et al. Nat Genet, 2017 Nov. PMID 28945253, Free PMC Article
    3. LGR6 promotes osteogenesis by activating the Wnt/β-catenin signaling pathway. Liu SL, et al. Biochem Biophys Res Commun, 2019 Oct 29. PMID 31500806
    4. Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing. Doherty L, et al. Bone, 2023 Apr. PMID 36708855, Free PMC Article
    5. Mechanical tension mobilizes Lgr6(+) epidermal stem cells to drive skin growth. Xue Y, et al. Sci Adv, 2022 Apr 29. PMID 35476447, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cardiomyocyte LGR6 alleviates ferroptosis in diabetic cardiomyopathy via regulating mitochondrial biogenesis.
      Title: Cardiomyocyte LGR6 alleviates ferroptosis in diabetic cardiomyopathy via regulating mitochondrial biogenesis.
    2. Resolution of post-lung transplant ischemia-reperfusion injury is modulated via Resolvin D1-FPR2 and Maresin 1-LGR6 signaling.
      Title: Resolution of post-lung transplant ischemia-reperfusion injury is modulated via Resolvin D1-FPR2 and Maresin 1-LGR6 signaling.
    3. Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing.
      Title: Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing.
    4. LGR6-dependent conditional inactivation of E-cadherin and p53 leads to invasive skin and mammary carcinomas in mice.
      Title: LGR6-dependent conditional inactivation of E-cadherin and p53 leads to invasive skin and mammary carcinomas in mice.
    5. Mechanical tension mobilizes Lgr6(+) epidermal stem cells to drive skin growth.
      Title: Mechanical tension mobilizes Lgr6(+) epidermal stem cells to drive skin growth.
    6. Mouse LGR6 regulates osteogenesis in vitro and in vivo through differential ligand use.
      Title: Mouse LGR6 regulates osteogenesis in vitro and in vivo through differential ligand use.
    7. LGR6 has a role in stimulating maresin 1's key proresolving functions of phagocytes
      Title: Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions.
    8. LGR6 is highly expressed in osteoblastic progenitors, and promotes osteogenesis by enhancing beta-catenin stability to strengthen the Wnt signaling pathway.
      Title: LGR6 promotes osteogenesis by activating the Wnt/β-catenin signaling pathway.
    9. Tumorigenesis was inhibited in Pot1b(-/-);p53(+/+) mice due to cellular senescence. Pot1b(-/-);p53(-/-) tumors also exhibited senescence, but proliferated and metastasized with expansion of Lgr6(+) stem cells indicative of senescence-associated secretory phenotype
      Title: Paracrine Interaction of Cancer Stem Cell Populations Is Regulated by the Senescence-Associated Secretory Phenotype (SASP).
    10. Leucine rich repeat containing G protein coupled receptor 6 (Lgr6) mRNA was found to be diminished in skin tumors.
      Title: Lgr6+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein-hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bone regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing G-protein coupled receptor 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033409.4 → NP_001028581.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform a precursor

      See identical proteins and their annotated locations for NP_001028581.1

      Status: VALIDATED

      Source sequence(s)
      AC117827, AC133097
      Consensus CDS
      CCDS15314.1
      UniProtKB/Swiss-Prot
      B2RUL8, Q3UVD5, Q80UB8, Q8R301
      Related
      ENSMUSP00000035444.8, ENSMUST00000044828.14
      Conserved Domains (5) summary
      smart00013
      Location:34 → 68
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:143 → 392
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:70 → 91
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:92 → 131
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:92 → 150
      LRR_8; Leucine rich repeat

    2. NM_001418305.1 → NP_001405234.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC117827, AC133097

    3. NM_001418307.1 → NP_001405236.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC117827, AC133097

    4. NM_001418308.1 → NP_001405237.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC117827
      UniProtKB/TrEMBL
      D3Z6S4

    5. NM_001418309.1 → NP_001405238.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC117827
      UniProtKB/TrEMBL
      D3Z6S4
      Related
      ENSMUSP00000122334.2, ENSMUST00000137968.8

    RNA

    1. NR_184714.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117827, AC133097

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      134911038..135033112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529714.1 → XP_006529777.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1

      Conserved Domains (4) summary
      smart00013
      Location:34 → 68
      LRRNT; Leucine rich repeat N-terminal domain
      PLN00113
      Location:60 → 411
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:70 → 91
      LRR_RI; leucine-rich repeat [structural motif]
      cd15362
      Location:538 → 814
      7tmA_LGR6; leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs

    2. XM_036165894.1 → XP_036021787.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X2

      Conserved Domains (4) summary
      smart00013
      Location:34 → 68
      LRRNT; Leucine rich repeat N-terminal domain
      PLN00113
      Location:60 → 427
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:70 → 91
      LRR_RI; leucine-rich repeat [structural motif]
      cd15362
      Location:520 → 796
      7tmA_LGR6; leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs

    3. XM_017321280.2 → XP_017176769.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X3

      Conserved Domains (4) summary
      smart00013
      Location:34 → 68
      LRRNT; Leucine rich repeat N-terminal domain
      PLN00113
      Location:60 → 435
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:70 → 91
      LRR_RI; leucine-rich repeat [structural motif]
      cd15362
      Location:562 → 838
      7tmA_LGR6; leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UVD5.1 GenPept UniProtKB/Swiss-Prot:Q3UVD5

    Gene LinkOut

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