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    Chi3l1 chitinase 3 like 1 [ Mus musculus (house mouse) ]

    Gene ID: 12654, updated on 27-Nov-2024

    Summary

    Official Symbol
    Chi3l1provided by MGI
    Official Full Name
    chitinase 3 like 1provided by MGI
    Primary source
    MGI:MGI:1340899
    See related
    Ensembl:ENSMUSG00000064246 AllianceGenome:MGI:1340899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gp39; Brp39; Chil1
    Summary
    Predicted to enable chitin binding activity. Involved in positive regulation of interleukin-8 production; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of protein phosphorylation. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; limb; liver; and skeleton. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to human CHI3L1 (chitinase 3 like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward lung adult (RPKM 398.3) See more
    Orthologs
    NEW
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    Genomic context

    See Chi3l1 in Genome Data Viewer
    Location:
    1 E4; 1 58.15 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134109894..134117769)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134182156..134190031)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene chitinase 1 Neighboring gene STARR-seq mESC enhancer starr_02318 Neighboring gene predicted gene, 46158 Neighboring gene STARR-positive B cell enhancer ABC_E1561 Neighboring gene myosin binding protein H Neighboring gene adenosine A1 receptor Neighboring gene predicted gene, 32221 Neighboring gene predicted gene, 24517

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of NF-kappaB-inducing kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to tumor necrosis factor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lung development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lung development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to interleukin-1 ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to interleukin-6 ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to mechanical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to tumor necrosis factor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    chitinase-3-like protein 1
    Names
    CGP-39
    GP-39
    YKL-40
    breast regression protein 39
    cartilage glycoprotein 39
    chitinase-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374626.1NP_001361555.1  chitinase-3-like protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC137104
      Consensus CDS
      CCDS87878.1
      Related
      ENSMUSP00000119205.2, ENSMUST00000156873.8
      Conserved Domains (1) summary
      cd02872
      Location:22378
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    2. NM_007695.4NP_031721.2  chitinase-3-like protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_031721.2

      Status: VALIDATED

      Source sequence(s)
      AC137104
      Consensus CDS
      CCDS48368.1
      UniProtKB/Swiss-Prot
      B0FEU7, D3Z2P2, Q3U291, Q4FJW9, Q61362, Q8BKL8, Q99J84
      Related
      ENSMUSP00000080717.4, ENSMUST00000082060.10
      Conserved Domains (1) summary
      cd02872
      Location:32388
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...

    RNA

    1. NR_174385.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC137104
    2. NR_174386.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC137104
    3. NR_174387.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC137104
    4. NR_174388.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC137104

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      134109894..134117769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)