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    Slc4a3 solute carrier family 4 (anion exchanger), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 20536, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc4a3provided by MGI
    Official Full Name
    solute carrier family 4 (anion exchanger), member 3provided by MGI
    Primary source
    MGI:MGI:109350
    See related
    Ensembl:ENSMUSG00000006576 AllianceGenome:MGI:109350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ae3; A930038D23Rik
    Summary
    Enables chloride:bicarbonate antiporter activity. Acts upstream of or within regulation of intracellular pH. Located in plasma membrane. Is expressed in nervous system and testis. Orthologous to human SLC4A3 (solute carrier family 4 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 74.1), heart adult (RPKM 43.5) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc4a3 in Genome Data Viewer
    Location:
    1 C4; 1 39.16 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75522688..75536075)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75546044..75559431)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5772 Neighboring gene STARR-positive B cell enhancer ABC_E5773 Neighboring gene STARR-positive B cell enhancer ABC_E4325 Neighboring gene serine/threonine kinase 11 interacting protein Neighboring gene predicted gene 15183 Neighboring gene STARR-positive B cell enhancer ABC_E4326 Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01363 Neighboring gene STARR-seq mESC enhancer starr_01364 Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bicarbonate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chloride:bicarbonate antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chloride:bicarbonate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bicarbonate transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pH reduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pH reduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of intracellular pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    anion exchange protein 3
    Names
    AE 3
    anion exchanger 3
    neuronal band 3-like protein
    solute carrier family 4 member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357149.1NP_001344078.1  anion exchange protein 3

      Status: VALIDATED

      Source sequence(s)
      AC115011
      Consensus CDS
      CCDS15080.1
      UniProtKB/Swiss-Prot
      P16283, Q9ERP5
      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:3211226
      ae; anion exchange protein
    2. NM_001357150.1NP_001344079.1  anion exchange protein 3

      Status: VALIDATED

      Source sequence(s)
      AC115011
      Consensus CDS
      CCDS15080.1
      UniProtKB/Swiss-Prot
      P16283, Q9ERP5
      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:3211226
      ae; anion exchange protein
    3. NM_009208.3NP_033234.2  anion exchange protein 3

      See identical proteins and their annotated locations for NP_033234.2

      Status: VALIDATED

      Source sequence(s)
      AK147218, BC080271, BY276474
      Consensus CDS
      CCDS15080.1
      UniProtKB/Swiss-Prot
      P16283, Q9ERP5
      UniProtKB/TrEMBL
      Q68EG4
      Related
      ENSMUSP00000116747.2, ENSMUST00000124341.8
      Conserved Domains (1) summary
      TIGR00834
      Location:3211226
      ae; anion exchange protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75522688..75536075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496450.4XP_006496513.1  anion exchange protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006496513.1

      UniProtKB/Swiss-Prot
      P16283, Q9ERP5
      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:3211226
      ae; anion exchange protein
    2. XM_006496453.3XP_006496516.1  anion exchange protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006496516.1

      UniProtKB/Swiss-Prot
      P16283, Q9ERP5
      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:3211226
      ae; anion exchange protein
    3. XM_036162945.1XP_036018838.1  anion exchange protein 3 isoform X2

      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:2511156
      ae; anion exchange protein
    4. XM_006496454.5XP_006496517.1  anion exchange protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006496517.1

      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:2511156
      ae; anion exchange protein
    5. XM_006496456.5XP_006496519.1  anion exchange protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006496519.1

      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:2511156
      ae; anion exchange protein
    6. XM_030252387.2XP_030108247.1  anion exchange protein 3 isoform X4

      Conserved Domains (1) summary
      cl26877
      Location:1736
      Band_3_cyto; Band 3 cytoplasmic domain
    7. XM_006496458.4XP_006496521.1  anion exchange protein 3 isoform X4

      See identical proteins and their annotated locations for XP_006496521.1

      Conserved Domains (1) summary
      cl26877
      Location:1736
      Band_3_cyto; Band 3 cytoplasmic domain
    8. XM_006496455.4XP_006496518.1  anion exchange protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006496518.1

      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:2511156
      ae; anion exchange protein
    9. XM_036162961.1XP_036018854.1  anion exchange protein 3 isoform X4

      Conserved Domains (1) summary
      cl26877
      Location:1736
      Band_3_cyto; Band 3 cytoplasmic domain
    10. XM_030252388.2XP_030108248.1  anion exchange protein 3 isoform X4

      Conserved Domains (1) summary
      cl26877
      Location:1736
      Band_3_cyto; Band 3 cytoplasmic domain
    11. XM_006496451.4XP_006496514.1  anion exchange protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006496514.1

      UniProtKB/Swiss-Prot
      P16283, Q9ERP5
      UniProtKB/TrEMBL
      Q68EG4
      Conserved Domains (1) summary
      TIGR00834
      Location:3211226
      ae; anion exchange protein
    12. XM_006496457.1XP_006496520.1  anion exchange protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006496520.1

      UniProtKB/TrEMBL
      Q9ERP4
      Conserved Domains (1) summary
      TIGR00834
      Location:1241029
      ae; anion exchange protein
    13. XM_036162963.1XP_036018856.1  anion exchange protein 3 isoform X4

      Conserved Domains (1) summary
      cl26877
      Location:1736
      Band_3_cyto; Band 3 cytoplasmic domain