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    Fer1l5 fer-1 like family member 5 [ Mus musculus (house mouse) ]

    Gene ID: 100534273, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fer1l5provided by MGI
    Official Full Name
    fer-1 like family member 5provided by MGI
    Primary source
    MGI:MGI:3616091
    See related
    Ensembl:ENSMUSG00000037432 AllianceGenome:MGI:3616091
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930533C12Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in T-tubule organization; membrane fusion; and plasma membrane repair. Predicted to be located in plasma membrane. Predicted to be active in T-tubule and cytoplasmic vesicle. Orthologous to human FER1L5 (fer-1 like family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 20.5) and thymus adult (RPKM 1.0) See more
    Orthologs
    human all
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    Genomic context

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    See Fer1l5 in Genome Data Viewer
    Location:
    1 B; 1 15.26 cM
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36411264..36461191)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36372183..36422110)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2541 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:36364755-36365011 Neighboring gene AT-rich interaction domain 5A Neighboring gene KAT8 regulatory NSL complex subunit 3 Neighboring gene microRNA 6898 Neighboring gene lectin, mannose-binding 2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:36501343-36501452 Neighboring gene STARR-positive B cell enhancer ABC_E5746 Neighboring gene predicted gene, 33401 Neighboring gene predicted gene, 33454 Neighboring gene cyclin M4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Testis-enriched ferlin, FER1L5, is required for Ca(2+)-activated acrosome reaction and male fertility. Morohoshi A, et al. Sci Adv, 2023 Jan 25. PMID 36696506, Free PMC Article
    2. Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 (Fer1L5) and mediate myoblast fusion. Posey AD Jr, et al. J Biol Chem, 2011 Mar 4. PMID 21177873, Free PMC Article
    3. Lineage-specific biology revealed by a finished genome assembly of the mouse. Church DM, et al. PLoS Biol, 2009 May 5. PMID 19468303, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Testis-enriched ferlin, FER1L5, is required for Ca[2+]-activated acrosome reaction and male fertility.
      Title: Testis-enriched ferlin, FER1L5, is required for Ca(2+)-activated acrosome reaction and male fertility.
    2. The characterization of Fer1L5 and its interaction with EHD1 and EHD2 underscores the complex requirement of ferlin proteins and mediators of endocytic recycling for membrane trafficking events during myotube formation
      Title: Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 (Fer1L5) and mediate myoblast fusion.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in T-tubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fer-1-like protein 5
    Names
    fer-1-like 5 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277076.3 → NP_001264005.1  fer-1-like protein 5

      See identical proteins and their annotated locations for NP_001264005.1

      Status: VALIDATED

      Source sequence(s)
      AC132456
      Consensus CDS
      CCDS78562.1
      UniProtKB/Swiss-Prot
      M1J7P7, P0DM40
      Related
      ENSMUSP00000142130.2, ENSMUST00000179162.7
      Conserved Domains (10) summary
      cd04011
      Location:164 → 271
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1077 → 1212
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04037
      Location:1487 → 1610
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08374
      Location:1722 → 1854
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:781 → 836
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:692 → 763
      FerB; FerB (NUC096) domain
      pfam08151
      Location:276 → 297
      FerI; FerI (NUC094) domain
      pfam08165
      Location:615 → 650
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1870 → 1984
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:5 → 134
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      36411264..36461191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163502.1 → XP_036019395.1  fer-1-like protein 5 isoform X1

      Conserved Domains (8) summary
      cd04011
      Location:164 → 271
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1077 → 1212
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04037
      Location:1447 → 1570
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      smart00693
      Location:781 → 836
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:691 → 763
      FerB; FerB (NUC096) domain
      pfam08151
      Location:276 → 297
      FerI; FerI (NUC094) domain
      pfam08165
      Location:615 → 650
      FerA; FerA (NUC095) domain
      cl14603
      Location:5 → 134
      C2; C2 domain

    2. XM_030253122.1 → XP_030108982.1  fer-1-like protein 5 isoform X2

      Conserved Domains (8) summary
      cd04011
      Location:164 → 271
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1034 → 1169
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04037
      Location:1444 → 1567
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      smart00693
      Location:743 → 793
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:692 → 743
      FerB; FerB (NUC096) domain
      pfam08151
      Location:276 → 297
      FerI; FerI (NUC094) domain
      pfam08165
      Location:615 → 650
      FerA; FerA (NUC095) domain
      cl14603
      Location:5 → 134
      C2; C2 domain

    3. XM_006495604.2 → XP_006495667.1  fer-1-like protein 5 isoform X4

      Conserved Domains (7) summary
      cd04011
      Location:164 → 271
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1077 → 1212
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      smart00693
      Location:781 → 836
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:692 → 763
      FerB; FerB (NUC096) domain
      pfam08151
      Location:276 → 297
      FerI; FerI (NUC094) domain
      pfam08165
      Location:615 → 650
      FerA; FerA (NUC095) domain
      cl14603
      Location:5 → 134
      C2; C2 domain

    4. XM_006495602.2 → XP_006495665.1  fer-1-like protein 5 isoform X3

      Conserved Domains (7) summary
      cd04011
      Location:164 → 271
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1077 → 1212
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      smart00693
      Location:781 → 836
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:692 → 763
      FerB; FerB (NUC096) domain
      pfam08151
      Location:276 → 297
      FerI; FerI (NUC094) domain
      pfam08165
      Location:615 → 650
      FerA; FerA (NUC095) domain
      cl14603
      Location:5 → 134
      C2; C2 domain

    5. XM_006495605.3 → XP_006495668.1  fer-1-like protein 5 isoform X5

      Conserved Domains (6) summary
      cd04011
      Location:164 → 271
      C2B_Ferlin; C2 domain second repeat in Ferlin
      smart00693
      Location:781 → 836
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:692 → 763
      FerB; FerB (NUC096) domain
      pfam08151
      Location:276 → 297
      FerI; FerI (NUC094) domain
      pfam08165
      Location:615 → 650
      FerA; FerA (NUC095) domain
      cl14603
      Location:5 → 134
      C2; C2 domain

    6. XM_030253213.1 → XP_030109073.1  fer-1-like protein 5 isoform X6

      Conserved Domains (5) summary
      cd04017
      Location:494 → 629
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04037
      Location:904 → 1027
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      smart00693
      Location:198 → 253
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:109 → 180
      FerB; FerB (NUC096) domain
      pfam08165
      Location:32 → 67
      FerA; FerA (NUC095) domain

    7. XM_030253230.1 → XP_030109090.1  fer-1-like protein 5 isoform X6

      Conserved Domains (5) summary
      cd04017
      Location:494 → 629
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04037
      Location:904 → 1027
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      smart00693
      Location:198 → 253
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:109 → 180
      FerB; FerB (NUC096) domain
      pfam08165
      Location:32 → 67
      FerA; FerA (NUC095) domain

    RNA

    1. XR_004941790.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_028631.1: Suppressed sequence

      Description
      NG_028631.1: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DM40.1 GenPept UniProtKB/Swiss-Prot:P0DM40

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials