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    Brinp2 bone morphogenic protein/retinoic acid inducible neural-specific 2 [ Mus musculus (house mouse) ]

    Gene ID: 240843, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Brinp2provided by MGI
    Official Full Name
    bone morphogenic protein/retinoic acid inducible neural-specific 2provided by MGI
    Primary source
    MGI:MGI:2443333
    See related
    Ensembl:ENSMUSG00000004031 AllianceGenome:MGI:2443333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam5b; mKIAA1747; 6430517E21Rik
    Summary
    Involved in cellular response to retinoic acid; central nervous system neuron differentiation; and negative regulation of mitotic cell cycle. Acts upstream of or within locomotion and nervous system development. Predicted to be located in extracellular region. Predicted to be active in cytoplasm; dendrite; and neuronal cell body. Is expressed in cortical antihem and cortical plate. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human BRINP2 (BMP/retinoic acid inducible neural specific 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 16.1), cortex adult (RPKM 14.4) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Brinp2 in Genome Data Viewer
    Location:
    1 H1; 1 68.27 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (158072835..158185096, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (158245265..158356528, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51855 Neighboring gene predicted gene, 39686 Neighboring gene STARR-seq mESC enhancer starr_02774 Neighboring gene STARR-seq mESC enhancer starr_02775 Neighboring gene VISTA enhancer mm1369 Neighboring gene STARR-seq mESC enhancer starr_02777 Neighboring gene astrotactin 1 Neighboring gene predicted gene, 37679 Neighboring gene microRNA 488 Neighboring gene STARR-seq mESC enhancer starr_02778 Neighboring gene predicted gene, 53639 Neighboring gene pappalysin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice Lacking Brinp2 or Brinp3, or Both, Exhibit Behaviors Consistent with Neurodevelopmental Disorders. Berkowicz SR, et al. Front Behav Neurosci, 2016. PMID 27826231, Free PMC Article
    2. Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells. Terashima M, et al. J Neurosci Res, 2010 May 15. PMID 20025061
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to retinoic acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in central nervous system neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BMP/retinoic acid-inducible neural-specific protein 2
    Names
    family with sequence similarity 5, member B
    protein FAM5B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207583.2 → NP_997466.2  BMP/retinoic acid-inducible neural-specific protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      BC076572, CO043107
      Consensus CDS
      CCDS15401.1
      UniProtKB/Swiss-Prot
      Q6DFY8, Q80T96
      Related
      ENSMUSP00000004133.9, ENSMUST00000004133.11
      Conserved Domains (1) summary
      smart00457
      Location:90 → 281
      MACPF; membrane-attack complex / perforin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      158072835..158185096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496837.2 → XP_006496900.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6DFY8, Q80T96
      Conserved Domains (1) summary
      smart00457
      Location:90 → 281
      MACPF; membrane-attack complex / perforin

    2. XM_006496836.2 → XP_006496899.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6DFY8, Q80T96
      Conserved Domains (1) summary
      smart00457
      Location:90 → 281
      MACPF; membrane-attack complex / perforin

    3. XM_011238810.2 → XP_011237112.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DFY8.1 GenPept UniProtKB/Swiss-Prot:Q6DFY8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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