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    Vcf2 VCP nuclear cofactor family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 382245, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Vcf2provided by MGI
    Official Full Name
    VCP nuclear cofactor family member 2provided by MGI
    Primary source
    MGI:MGI:1923420
    See related
    Ensembl:ENSMUSG00000041353 AllianceGenome:MGI:1923420
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem29; CXorf44-like; 2700081K05Rik; 6330540D07Rik
    Summary
    Predicted to be located in nuclear envelope. Orthologous to human FAM156A (family with sequence similarity 156 member A) and FAM156B (family with sequence similarity 156 member B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 6.7), CNS E14 (RPKM 6.1) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vcf2 in Genome Data Viewer
    Location:
    X F3; X 68.46 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (149180771..149250327, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (150397775..150495036, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 15104 Neighboring gene methylphosphate capping enzyme pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chrX:146893310-146893611 Neighboring gene zinc finger CCCH type containing 14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48069 Neighboring gene STARR-seq mESC enhancer starr_48070 Neighboring gene apurinic/apyrimidinic endonuclease 2 Neighboring gene microRNA 3620 Neighboring gene Alas2R1 erythroid cis-regulatory module Neighboring gene aminolevulinic acid synthase 2, erythroid Neighboring gene Alas2R3 erythroid cis-regulatory module

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Abundance of female-biased and paucity of male-biased somatically expressed genes on the mouse X-chromosome. Reinius B, et al. BMC Genomics, 2012 Nov 10. PMID 23140559, Free PMC Article
    2. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein VCF2
    Names
    transmembrane protein 29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164683.2 → NP_001158155.1  protein VCF2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL808140, BY288280
      Consensus CDS
      CCDS53218.1
      UniProtKB/TrEMBL
      A2ANF5
      Related
      ENSMUSP00000134594.2, ENSMUST00000173996.8
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 167
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    2. NM_001164684.2 → NP_001158156.1  protein VCF2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AK018228, AL808140
      Consensus CDS
      CCDS53218.1
      UniProtKB/TrEMBL
      A2ANF5
      Related
      ENSMUSP00000053632.2, ENSMUST00000059256.8
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 167
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    3. NM_001164686.1 → NP_001158158.1  protein VCF2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL808140, BC058428, CK624690
      Consensus CDS
      CCDS53219.1
      UniProtKB/TrEMBL
      E9PZH0
      Related
      ENSMUSP00000132541.2, ENSMUST00000163233.2
      Conserved Domains (1) summary
      pfam15434
      Location:17 → 123
      FAM104; Family 104

    4. NM_001359038.1 → NP_001345967.1  protein VCF2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL808140, BC058428, CX205977
      Related
      ENSMUST00000141948.8
      Conserved Domains (1) summary
      pfam15434
      Location:3 → 113
      FAM104; Family 104

    5. NM_001359039.1 → NP_001345968.1  protein VCF2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL808140
      Consensus CDS
      CCDS53218.1
      UniProtKB/TrEMBL
      A2ANF5
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 167
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    RNA

    1. NR_152724.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA690651, AL808140, BC058428

    2. NR_152725.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK012546, AL808140, BC058428
      Related
      ENSMUST00000148968.8

    3. NR_152726.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK165152, AL808140
      Related
      ENSMUST00000127532.2

    4. NR_152727.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK165152, AW491285, BF468601

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      149180771..149250327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247836.3 → XP_011246138.1  protein VCF2 isoform X2

      Conserved Domains (1) summary
      pfam15434
      Location:15 → 126
      FAM104; Family 104

    2. XM_006528894.3 → XP_006528957.1  protein VCF2 isoform X1

      Conserved Domains (1) summary
      pfam15434
      Location:21 → 131
      FAM104; Family 104

    3. XM_030251377.1 → XP_030107237.1  protein VCF2 isoform X3

      Conserved Domains (1) summary
      pfam15434
      Location:3 → 113
      FAM104; Family 104
    Nucleotide Protein Strain
    Heading Accession and Version

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