Colec10 collectin sub-family member 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Colec10provided by MGI
Official Full Name: collectin sub-family member 10provided by MGI
Primary source: MGI:MGI:3606482
See related: Ensembl:ENSMUSG00000038591 AllianceGenome:MGI:3606482
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CL-L1
Summary: Enables D-mannose binding activity. Predicted to be involved in several processes, including complement activation, lectin pathway; cranial skeletal system development; and positive regulation of opsonization. Predicted to be located in cytoplasm. Predicted to be part of collagen trimer. Predicted to be active in extracellular space and multivesicular body. Is expressed in several structures, including extraembryonic component; gut; liver; musculature; and testis. Human ortholog(s) of this gene implicated in 3MC syndrome 3. Orthologous to human COLEC10 (collectin subfamily member 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E18 (RPKM 6.6), placenta adult (RPKM 5.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 21.15 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (54274170..54329755)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (54410774..54466360)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis.
Title: The C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis.
During acute-phase responses, the CL-L1 levels display only minor variations. In serum, CL-L1 was found in complexes with mannan-binding lectin-associated serine proteases, suggesting a role in the lectin pathway of complement activation.
Title: Investigations on collectin liver 1.
mouse collectin liver 1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q
Title: Molecular cloning of mouse collectin liver 1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489542

Colec10 (e-PCR), detects polymorphism
- UniSTS:479308

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-mannose binding	IDA Inferred from Direct Assay more info	PubMed
enables chemoattractant activity	IEA Inferred from Electronic Annotation more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in complement activation, lectin pathway	IEA Inferred from Electronic Annotation more info
involved_in complement activation, lectin pathway	ISO Inferred from Sequence Orthology more info
involved_in cranial skeletal system development	IEA Inferred from Electronic Annotation more info
involved_in cranial skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in defense response	NAS Non-traceable Author Statement more info	PubMed
involved_in embryo development ending in birth or egg hatching	NAS Non-traceable Author Statement more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	NAS Non-traceable Author Statement more info	PubMed
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of opsonization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of opsonization	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: collectin-10

Names: collectin liver 1; collectin liver protein 1; collectin-L1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173422.3 → NP_775598.2 collectin-10 precursor

See identical proteins and their annotated locations for NP_775598.2

Status: VALIDATED

Source sequence(s)

AK028423, BC108945

Consensus CDS

CCDS27469.1

UniProtKB/Swiss-Prot

Q8C1C5, Q8CF98

Related

ENSMUSP00000037867.4, ENSMUST00000036737.4

Conserved Domains (2) summary

cd03591
Location:157 → 272

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:45 → 93

Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

54274170..54329755

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245615.2 → XP_011243917.1 collectin-10 isoform X1

See identical proteins and their annotated locations for XP_011243917.1

Conserved Domains (1) summary

cd03591
Location:76 → 191

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
XM_011245616.3 → XP_011243918.1 collectin-10 isoform X1

See identical proteins and their annotated locations for XP_011243918.1

Conserved Domains (1) summary

cd03591
Location:76 → 191

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)