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    Ilkap integrin-linked kinase-associated serine/threonine phosphatase 2C [ Mus musculus (house mouse) ]

    Gene ID: 67444, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ilkapprovided by MGI
    Official Full Name
    integrin-linked kinase-associated serine/threonine phosphatase 2Cprovided by MGI
    Primary source
    MGI:MGI:1914694
    See related
    Ensembl:ENSMUSG00000026309 AllianceGenome:MGI:1914694
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PP2C-DELTA; 0710007A14Rik; 1600009O09Rik
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in regulation of nuclear cell cycle DNA replication and signal transduction. Predicted to be located in cytoplasm. Is expressed in central nervous system; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human ILKAP (ILK associated serine/threonine phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 16.1), CNS E14 (RPKM 12.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ilkap in Genome Data Viewer
    Location:
    1 D; 1 46.11 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91301568..91326566, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91373846..91398844, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene espin-like Neighboring gene kelch-like 30 Neighboring gene erythroferrone Neighboring gene RIKEN cDNA 1700020N18 gene Neighboring gene STARR-positive B cell enhancer ABC_E5783 Neighboring gene hairy and enhancer of split 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm  

    General protein information

    Preferred Names
    integrin-linked kinase-associated serine/threonine phosphatase 2C
    NP_001342081.1
    NP_075832.1
    XP_006529870.1
    XP_006529871.1
    XP_006529872.1
    XP_006529873.1
    XP_006529874.1
    XP_006529875.1
    XP_006529876.1
    XP_006529877.1
    XP_006529878.1
    XP_030098240.1
    XP_030098245.1
    XP_030098247.1
    XP_030098259.1
    XP_030098261.1
    XP_030098264.1
    XP_030098265.1
    XP_030098270.1
    XP_030098273.1
    XP_030098275.1
    XP_030098278.1
    XP_030098281.1
    XP_030098282.1
    XP_030098284.1
    XP_030098286.1
    XP_036009024.1
    XP_036009025.1
    XP_036009026.1
    XP_036009027.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355152.1NP_001342081.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC110510
      Conserved Domains (1) summary
      cd00143
      Location:1226
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    2. NM_023343.3NP_075832.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform 1

      See identical proteins and their annotated locations for NP_075832.1

      Status: VALIDATED

      Source sequence(s)
      AC110510
      Consensus CDS
      CCDS15162.1
      UniProtKB/Swiss-Prot
      Q05CC3, Q8R0F6
      Related
      ENSMUSP00000027534.7, ENSMUST00000027534.13
      Conserved Domains (1) summary
      cd00143
      Location:108390
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      91301568..91326566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242380.2XP_030098240.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X7

      Conserved Domains (1) summary
      cd00143
      Location:102345
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    2. XM_006529810.5XP_006529873.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X5

      Conserved Domains (1) summary
      cd00143
      Location:108351
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    3. XM_006529807.5XP_006529870.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X1

      Conserved Domains (1) summary
      cd00143
      Location:108346
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    4. XM_030242387.2XP_030098247.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X11

      Conserved Domains (1) summary
      cd00143
      Location:86259
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    5. XM_030242415.2XP_030098275.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X14

      Conserved Domains (1) summary
      cd00143
      Location:1231
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    6. XM_030242418.2XP_030098278.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X14

      Conserved Domains (1) summary
      cd00143
      Location:1231
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    7. XM_030242413.2XP_030098273.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X13

      Conserved Domains (1) summary
      cd00143
      Location:1226
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    8. XM_030242421.2XP_030098281.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X14

      Conserved Domains (1) summary
      cd00143
      Location:1231
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    9. XM_036153131.1XP_036009024.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X9

      Conserved Domains (1) summary
      cd00143
      Location:102314
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    10. XM_006529808.5XP_006529871.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X2

      Conserved Domains (1) summary
      cd00143
      Location:102384
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    11. XM_006529813.5XP_006529876.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X8

      Conserved Domains (1) summary
      cd00143
      Location:108320
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    12. XM_030242385.2XP_030098245.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X10

      Conserved Domains (1) summary
      cd00143
      Location:86298
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    13. XM_006529812.5XP_006529875.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X6

      Conserved Domains (1) summary
      cd00143
      Location:80362
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    14. XM_006529811.5XP_006529874.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X4

      See identical proteins and their annotated locations for XP_006529874.1

      Conserved Domains (1) summary
      cd00143
      Location:86368
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    15. XM_006529815.4XP_006529878.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

      See identical proteins and their annotated locations for XP_006529878.1

      Conserved Domains (1) summary
      cd00143
      Location:1270
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    16. XM_030242422.2XP_030098282.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X15

      Conserved Domains (1) summary
      cd00143
      Location:1200
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    17. XM_030242424.2XP_030098284.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X15

      Conserved Domains (1) summary
      cd00143
      Location:1200
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    18. XM_030242426.2XP_030098286.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X15

      Conserved Domains (1) summary
      cd00143
      Location:1200
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    19. XM_030242410.2XP_030098270.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

      Conserved Domains (1) summary
      cd00143
      Location:1270
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    20. XM_030242401.2XP_030098261.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

      Conserved Domains (1) summary
      cd00143
      Location:1270
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    21. XM_030242399.2XP_030098259.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

      Conserved Domains (1) summary
      cd00143
      Location:1270
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    22. XM_006529814.4XP_006529877.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

      See identical proteins and their annotated locations for XP_006529877.1

      Conserved Domains (1) summary
      cd00143
      Location:1270
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    23. XM_036153132.1XP_036009025.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

      Conserved Domains (1) summary
      cd00143
      Location:1270
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    24. XM_030242405.2XP_030098265.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

      Conserved Domains (1) summary
      cd00143
      Location:1270
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    25. XM_030242404.2XP_030098264.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

      Conserved Domains (1) summary
      cd00143
      Location:1270
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    26. XM_036153133.1XP_036009026.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

      Conserved Domains (1) summary
      cd00143
      Location:1270
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    27. XM_036153134.1XP_036009027.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

      Conserved Domains (1) summary
      cd00143
      Location:1270
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    28. XM_006529809.5XP_006529872.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X3

      Conserved Domains (1) summary
      cd00143
      Location:100382
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
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