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    Cep350 centrosomal protein 350 [ Mus musculus (house mouse) ]

    Gene ID: 74081, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cep350provided by MGI
    Official Full Name
    centrosomal protein 350provided by MGI
    Primary source
    MGI:MGI:1921331
    See related
    Ensembl:ENSMUSG00000033671 AllianceGenome:MGI:1921331
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933409L06Rik; 6430546F08Rik
    Summary
    Predicted to enable microtubule binding activity. Acts upstream of or within non-motile cilium assembly and protein localization to centrosome. Predicted to be located in centriole. Predicted to be active in centrosome. Is expressed in brain; lung; and testis. Orthologous to human CEP350 (centrosomal protein 350). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 5.6), CNS E18 (RPKM 3.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cep350 in Genome Data Viewer
    Location:
    1 G3; 1 67.64 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (155720710..155848976, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (155844964..155973270, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02727 Neighboring gene LIM homeobox protein 4 Neighboring gene quiescin Q6 sulfhydryl oxidase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:157659814-157660115 Neighboring gene predicted gene, 36934 Neighboring gene predicted gene, 51652 Neighboring gene STARR-positive B cell enhancer ABC_E9186 Neighboring gene predicted gene, 23744 Neighboring gene predicted gene, 53631 Neighboring gene torsin A interacting protein 1 Neighboring gene predicted gene, 51653

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    General gene information

    Clone Names

    • MGC107324

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in cell projection  
    located_in centriole  
    located_in centriole  
    located_in centrosome  
    is_active_in centrosome  
    located_in cytoplasm  
    located_in nucleus  
    located_in spindle  

    General protein information

    Preferred Names
    centrosome-associated protein 350

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039184.2NP_001034273.1  centrosome-associated protein 350

      Status: VALIDATED

      Source sequence(s)
      AC120391, AC121314
      Consensus CDS
      CCDS48400.1
      UniProtKB/Swiss-Prot
      A0A1D5RMJ4, D3YTP2, E9Q309, Q6A062, Q8BXM7
      Related
      ENSMUSP00000120085.2, ENSMUST00000138762.8
      Conserved Domains (3) summary
      pfam01302
      Location:24862550
      CAP_GLY; CAP-Gly domain
      cl25632
      Location:13171439
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      cl26511
      Location:15632290
      Neuromodulin_N; Gap junction protein N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      155720710..155848976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529903.5XP_006529966.1  centrosome-associated protein 350 isoform X3

      Conserved Domains (5) summary
      PTZ00121
      Location:13351813
      PTZ00121; MAEBL; Provisional
      COG5022
      Location:20942374
      COG5022; Myosin heavy chain [General function prediction only]
      COG5244
      Location:25302807
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      PTZ00108
      Location:18892150
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam01302
      Location:25302594
      CAP_GLY; CAP-Gly domain
    2. XM_006529907.5XP_006529970.1  centrosome-associated protein 350 isoform X9

      Conserved Domains (4) summary
      TIGR01843
      Location:13181440
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      PTZ00121
      Location:15642291
      PTZ00121; MAEBL; Provisional
      COG5244
      Location:24872764
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:24872551
      CAP_GLY; CAP-Gly domain
    3. XM_030243199.2XP_030099059.1  centrosome-associated protein 350 isoform X5

      Conserved Domains (5) summary
      PTZ00121
      Location:13651812
      PTZ00121; MAEBL; Provisional
      COG5022
      Location:20922372
      COG5022; Myosin heavy chain [General function prediction only]
      COG5244
      Location:25282805
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      PTZ00108
      Location:18872148
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam01302
      Location:25282592
      CAP_GLY; CAP-Gly domain
    4. XM_006529906.5XP_006529969.1  centrosome-associated protein 350 isoform X8

      Conserved Domains (4) summary
      TIGR01843
      Location:13181440
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      PTZ00121
      Location:15652292
      PTZ00121; MAEBL; Provisional
      COG5244
      Location:24882765
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:24882552
      CAP_GLY; CAP-Gly domain
    5. XM_006529904.5XP_006529967.1  centrosome-associated protein 350 isoform X4

      Conserved Domains (7) summary
      TIGR01843
      Location:13181440
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      PTZ00121
      Location:14861813
      PTZ00121; MAEBL; Provisional
      COG5022
      Location:20932373
      COG5022; Myosin heavy chain [General function prediction only]
      COG5244
      Location:25292806
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      PRK12704
      Location:16771779
      PRK12704; phosphodiesterase; Provisional
      PTZ00108
      Location:18882149
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam01302
      Location:25292593
      CAP_GLY; CAP-Gly domain
    6. XM_030243200.2XP_030099060.1  centrosome-associated protein 350 isoform X7

      Conserved Domains (4) summary
      TIGR01843
      Location:13181440
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      PTZ00121
      Location:15662293
      PTZ00121; MAEBL; Provisional
      COG5244
      Location:24892766
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:24892553
      CAP_GLY; CAP-Gly domain
    7. XM_006529902.5XP_006529965.1  centrosome-associated protein 350 isoform X2

      Conserved Domains (7) summary
      TIGR01843
      Location:13181440
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      PTZ00121
      Location:13451814
      PTZ00121; MAEBL; Provisional
      COG5022
      Location:20942374
      COG5022; Myosin heavy chain [General function prediction only]
      COG5244
      Location:25302807
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      PRK12704
      Location:16781780
      PRK12704; phosphodiesterase; Provisional
      PTZ00108
      Location:18892150
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam01302
      Location:25302594
      CAP_GLY; CAP-Gly domain
    8. XM_006529905.5XP_006529968.1  centrosome-associated protein 350 isoform X6

      Conserved Domains (4) summary
      PTZ00121
      Location:13361981
      PTZ00121; MAEBL; Provisional
      COG5244
      Location:24902767
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam02463
      Location:16812324
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam01302
      Location:24902554
      CAP_GLY; CAP-Gly domain
    9. XM_006529900.5XP_006529963.1  centrosome-associated protein 350 isoform X1

      Conserved Domains (5) summary
      PTZ00121
      Location:13361814
      PTZ00121; MAEBL; Provisional
      COG5022
      Location:20952375
      COG5022; Myosin heavy chain [General function prediction only]
      COG5244
      Location:25312808
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      PTZ00108
      Location:18902151
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam01302
      Location:25312595
      CAP_GLY; CAP-Gly domain
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