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    Rab4b RAB4B, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19342, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab4bprovided by MGI
    Official Full Name
    RAB4B, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:105071
    See related
    Ensembl:ENSMUSG00000053291 AllianceGenome:MGI:105071
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500031G17Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including D-glucose import; early endosome to Golgi transport; and endosomal vesicle fusion. Located in mitochondrion. Is expressed in nasal septum and skeleton. Orthologous to human RAB4B (RAB4B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 39.5), cerebellum adult (RPKM 38.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rab4b in Genome Data Viewer
    Location:
    7 A3; 7 15.84 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26867858..26878308, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27168433..27178883, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily t, polypeptide 4 Neighboring gene egl-9 family hypoxia-inducible factor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr7:27952094-27952395 Neighboring gene STARR-positive B cell enhancers ABC_E1725 and ABC_E288 Neighboring gene microRNA 3101 Neighboring gene MIA SH3 domain containing Neighboring gene small nuclear ribonucleoprotein polypeptide A Neighboring gene STARR-positive B cell enhancer ABC_E3707 Neighboring gene actin maturation protease

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    General gene information

    Potential readthrough

    Included gene: Mia

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity  
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    Process Evidence Code Pubs
    involved_in D-glucose import  
    involved_in D-glucose import  
    involved_in Rab protein signal transduction  
    involved_in early endosome to Golgi transport  
    involved_in early endosome to Golgi transport  
    involved_in endosomal vesicle fusion  
    involved_in endosomal vesicle fusion  
    involved_in protein transport  
    involved_in regulation of endocytosis  
    involved_in vesicle-mediated transport  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in early endosome membrane  
    is_active_in early endosome membrane  
    is_active_in insulin-responsive compartment  
    located_in insulin-responsive compartment  
    located_in insulin-responsive compartment  
    located_in mitochondrion PubMed 
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    is_active_in recycling endosome  
    located_in recycling endosome  
    located_in recycling endosome  
    is_active_in synaptic vesicle membrane  

    General protein information

    Preferred Names
    ras-related protein Rab-4B
    NP_083667.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029391.2NP_083667.1  ras-related protein Rab-4B

      See identical proteins and their annotated locations for NP_083667.1

      Status: PROVISIONAL

      Source sequence(s)
      AC157553
      Consensus CDS
      CCDS21012.1
      UniProtKB/Swiss-Prot
      Q91ZR1
      UniProtKB/TrEMBL
      Q3USC3, Q4V9W8
      Related
      ENSMUSP00000090727.7, ENSMUST00000093040.13
      Conserved Domains (1) summary
      cd04113
      Location:9169
      Rab4; Rab GTPase family 4 (Rab4)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      26867858..26878308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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