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    Chrna6 cholinergic receptor, nicotinic, alpha polypeptide 6 [ Mus musculus (house mouse) ]

    Gene ID: 11440, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chrna6provided by MGI
    Official Full Name
    cholinergic receptor, nicotinic, alpha polypeptide 6provided by MGI
    Primary source
    MGI:MGI:106213
    See related
    Ensembl:ENSMUSG00000031491 AllianceGenome:MGI:106213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acra6; Nica6
    Summary
    Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within membrane depolarization and regulation of dopamine secretion. Part of acetylcholine-gated channel complex. Is active in dopaminergic synapse; postsynaptic membrane; and presynaptic membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in alcohol use disorder; cocaine abuse; and nicotine dependence. Orthologous to human CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Chrna6 in Genome Data Viewer
    Location:
    8 A2; 8 16.02 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (27893240..27903972, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (27403212..27413944, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53409 Neighboring gene cholinergic receptor, nicotinic, beta polypeptide 3 Neighboring gene predicted gene, 24410 Neighboring gene ankyrin repeat domain 69 Neighboring gene STARR-seq mESC enhancer starr_21038 Neighboring gene STARR-seq mESC enhancer starr_21039 Neighboring gene STARR-seq mESC enhancer starr_21040

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex  
    part_of acetylcholine-gated channel complex PubMed 
    is_active_in dopaminergic synapse PubMed 
    is_active_in dopaminergic synapse PubMed 
    is_active_in neuron projection  
    is_active_in plasma membrane  
    is_active_in postsynaptic membrane PubMed 
    is_active_in postsynaptic membrane PubMed 
    is_active_in postsynaptic membrane  
    is_active_in presynaptic membrane PubMed 
    is_active_in presynaptic membrane PubMed 
    is_active_in presynaptic membrane  
    part_of protein-containing complex  
    is_active_in synapse  

    General protein information

    Preferred Names
    neuronal acetylcholine receptor subunit alpha-6
    Names
    acetylcholine receptor alpha 6 neural
    alpha6 nAChR
    nicotinic acetylcholine receptor subunit alpha 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021369.2NP_067344.2  neuronal acetylcholine receptor subunit alpha-6 precursor

      See identical proteins and their annotated locations for NP_067344.2

      Status: VALIDATED

      Source sequence(s)
      BC031985
      Consensus CDS
      CCDS40312.1
      UniProtKB/Swiss-Prot
      Q3UEY4, Q8K0A7, Q9R0W9
      UniProtKB/TrEMBL
      Q6PW44
      Related
      ENSMUSP00000033882.9, ENSMUST00000033882.10
      Conserved Domains (3) summary
      TIGR00860
      Location:15484
      LIC; Cation transporter family protein
      pfam02931
      Location:34240
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:247483
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      27893240..27903972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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