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    Ctnna3 catenin alpha 3 [ Mus musculus (house mouse) ]

    Gene ID: 216033, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ctnna3provided by MGI
    Official Full Name
    catenin alpha 3provided by MGI
    Primary source
    MGI:MGI:2661445
    See related
    Ensembl:ENSMUSG00000060843 AllianceGenome:MGI:2661445
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vr22; Catna3; 4933408A16; 4930429L08Rik
    Summary
    Predicted to enable actin filament binding activity and beta-catenin binding activity. Involved in cell-cell adhesion. Located in adherens junction; fascia adherens; and lamellipodium. Is expressed in cardiac muscle tissue and skin of male preputial swelling. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular dysplasia 13. Orthologous to human CTNNA3 (catenin alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 9.1), heart adult (RPKM 3.0) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Ctnna3 in Genome Data Viewer
    Location:
    10 B4- B5.1; 10 32.57 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (63265877..64841174)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63430098..65003667)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2940 Neighboring gene STARR-positive B cell enhancer ABC_E1121 Neighboring gene nuclear encoded tRNA serine 3 (anticodon TGA) Neighboring gene ring finger protein 7 like Neighboring gene STARR-seq mESC enhancer starr_26935 Neighboring gene STARR-seq mESC enhancer starr_26936 Neighboring gene predicted gene, 30644 Neighboring gene STARR-seq mESC enhancer starr_26937 Neighboring gene leucine rich repeat transmembrane neuronal 3 Neighboring gene STARR-seq mESC enhancer starr_26939 Neighboring gene STARR-seq mESC enhancer starr_26940 Neighboring gene STARR-seq mESC enhancer starr_26941 Neighboring gene STARR-seq mESC enhancer starr_26942 Neighboring gene STARR-seq mESC enhancer starr_26944 Neighboring gene STARR-seq mESC enhancer starr_26945 Neighboring gene STARR-seq mESC enhancer starr_26947 Neighboring gene STARR-seq mESC enhancer starr_26948 Neighboring gene STARR-seq mESC enhancer starr_26949 Neighboring gene predicted gene, 51834 Neighboring gene predicted gene 28881

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding  
    enables actin filament binding  
    enables beta-catenin binding  
    enables beta-catenin binding  
    enables beta-catenin binding  
    enables cadherin binding PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in adherens junction  
    located_in adherens junction PubMed 
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in desmosome  
    is_active_in fascia adherens  
    located_in fascia adherens PubMed 
    located_in fascia adherens  
    located_in fascia adherens  
    located_in lamellipodium PubMed 

    General protein information

    Preferred Names
    catenin alpha-3
    Names
    alpha T-catenin
    alpha-catenin-like protein
    alphaT-catenin
    cadherin-associated protein
    catenin (cadherin associated protein), alpha 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164376.1NP_001157848.1  catenin alpha-3 isoform 1

      See identical proteins and their annotated locations for NP_001157848.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK142745
      Consensus CDS
      CCDS23901.1
      UniProtKB/Swiss-Prot
      Q3UQ61, Q65CL1, Q8C0N3
      UniProtKB/TrEMBL
      A4GE64
      Related
      ENSMUSP00000101080.2, ENSMUST00000105440.8
      Conserved Domains (1) summary
      pfam01044
      Location:18856
      Vinculin; Vinculin family
    2. NM_001164519.1NP_001157991.1  catenin alpha-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC113544, AC153511, AC153513, AC153514, AC153926, AC158604, AC158638, AC158806
      UniProtKB/TrEMBL
      A4GE65
      Conserved Domains (1) summary
      pfam01044
      Location:15589
      Vinculin; Vinculin family
    3. NM_177612.3NP_808280.2  catenin alpha-3 isoform 1

      See identical proteins and their annotated locations for NP_808280.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC153513, AK030166, AK142745
      Consensus CDS
      CCDS23901.1
      UniProtKB/Swiss-Prot
      Q3UQ61, Q65CL1, Q8C0N3
      UniProtKB/TrEMBL
      A4GE64
      Related
      ENSMUSP00000101081.2, ENSMUST00000105441.8
      Conserved Domains (1) summary
      pfam01044
      Location:18856
      Vinculin; Vinculin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      63265877..64841174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513475.4XP_006513538.1  catenin alpha-3 isoform X1

      See identical proteins and their annotated locations for XP_006513538.1

      UniProtKB/Swiss-Prot
      Q3UQ61, Q65CL1, Q8C0N3
      UniProtKB/TrEMBL
      A4GE64
      Conserved Domains (1) summary
      pfam01044
      Location:18856
      Vinculin; Vinculin family
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