Lin7a lin-7 homolog A, crumbs cell polarity complex component [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lin7aprovided by MGI
Official Full Name: lin-7 homolog A, crumbs cell polarity complex componentprovided by MGI
Primary source: MGI:MGI:2135609
See related: Ensembl:ENSMUSG00000019906 AllianceGenome:MGI:2135609
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Veli; Veli1; LIN-7A; MALS-1; TIP-33
Summary: Predicted to enable L27 domain binding activity; PDZ domain binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within inner ear development; neurotransmitter secretion; and synaptic vesicle transport. Located in basolateral plasma membrane. Is expressed in glans of male genital tubercle; lung; nervous system; paraxial mesenchyme; and sensory organ. Orthologous to human LIN7A (lin-7 homolog A, crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cerebellum adult (RPKM 13.2), testis adult (RPKM 8.6) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D1; 10 55.83 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (107107410..107261007)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (107271549..107425146)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LIN7 is a novel regulator of IRSp53.
Title: LIN7 regulates the filopodium- and neurite-promoting activity of IRSp53.
findings show that AQP1 plays a role inside the cells through Lin-7/beta-catenin interactionsuggesting that AQP1 plays a global physiological role
Title: AQP1 is not only a water channel: it contributes to cell migration through Lin7/beta-catenin.
LIN7-IRSp53 association plays a role during assembly of functional tight junctions and surface polarization in epithelial cells
Title: LIN7 mediates the recruitment of IRSp53 to tight junctions.
analysis of structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins
Title: A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L27 domain binding	IEA Inferred from Electronic Annotation more info
enables L27 domain binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear development	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neurotransmitter secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic assembly at neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic vesicle transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MPP7-DLG1-LIN7 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
located_in transport vesicle membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: protein lin-7 homolog A

Names: lin 7 homolog a; lin-7 homolog A; mammalian LIN-7 1; mammalian lin-seven protein 1; vertebrate homolog of C. elegans Lin-7 type 1; vertebrate lin-7 homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033223.3 → NP_001028395.1 protein lin-7 homolog A isoform 2

See identical proteins and their annotated locations for NP_001028395.1

Status: VALIDATED

Source sequence(s)

AC116325, AC140338, AC155168

Consensus CDS

CCDS36050.1

UniProtKB/TrEMBL

Q3TUM0

Related

ENSMUSP00000100916.4, ENSMUST00000105280.5

Conserved Domains (1) summary

cd00992
Location:2 → 65

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001039354.2 → NP_001034443.1 protein lin-7 homolog A isoform 1

See identical proteins and their annotated locations for NP_001034443.1

Status: VALIDATED

Source sequence(s)

AC116325, AC140338, AC155168

Consensus CDS

CCDS24160.1

UniProtKB/Swiss-Prot

Q8JZS0

Related

ENSMUSP00000020057.9, ENSMUST00000020057.16

Conserved Domains (2) summary

smart00569
Location:31 → 83

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd00992
Location:106 → 187

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001284329.2 → NP_001271258.1 protein lin-7 homolog A isoform 2

See identical proteins and their annotated locations for NP_001271258.1

Status: VALIDATED

Source sequence(s)

AC116325, AC140338, AC155168

Consensus CDS

CCDS36050.1

UniProtKB/TrEMBL

Q3TUM0

Related

ENSMUSP00000151715.2, ENSMUST00000218031.2

Conserved Domains (1) summary

cd00992
Location:2 → 65

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

107107410..107261007

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513031.4 → XP_006513094.1 protein lin-7 homolog A isoform X1

Conserved Domains (2) summary

cd00992
Location:94 → 175

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl02672
Location:31 → 71

L27; L27 domain
XM_006513032.2 → XP_006513095.1 protein lin-7 homolog A isoform X2

See identical proteins and their annotated locations for XP_006513095.1

Conserved Domains (1) summary

cd00992
Location:35 → 116

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_036155485.1 → XP_036011378.1 protein lin-7 homolog A isoform X3

UniProtKB/TrEMBL

Q3TUM0

Conserved Domains (1) summary

cd00992
Location:2 → 65

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...