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    Slc4a5 solute carrier family 4, sodium bicarbonate cotransporter, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 232156, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc4a5provided by MGI
    Official Full Name
    solute carrier family 4, sodium bicarbonate cotransporter, member 5provided by MGI
    Primary source
    MGI:MGI:2443220
    See related
    Ensembl:ENSMUSG00000068323 AllianceGenome:MGI:2443220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C330006M16; C330016K18Rik
    Summary
    Enables sodium:bicarbonate symporter activity. Acts upstream of or within several processes, including cerebrospinal fluid secretion; mitochondrion distribution; and retina development in camera-type eye. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including nervous system; retina; and thyroid gland. Orthologous to human SLC4A5 (solute carrier family 4 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 8.8), duodenum adult (RPKM 3.6) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc4a5 in Genome Data Viewer
    Location:
    6 C3; 6 35.94 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83184561..83281927)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83207580..83304945)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700003E16 gene Neighboring gene STARR-positive B cell enhancer ABC_E6447 Neighboring gene STARR-seq mESC enhancer starr_16458 Neighboring gene predicted gene 15624 Neighboring gene dynactin 1 Neighboring gene STARR-seq mESC enhancer starr_16459 Neighboring gene STARR-positive B cell enhancer ABC_E4836 Neighboring gene STARR-positive B cell enhancer ABC_E1323 Neighboring gene methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase Neighboring gene STARR-positive B cell enhancer ABC_E6448 Neighboring gene STARR-seq mESC enhancer starr_16463 Neighboring gene MOB kinase activator 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in bicarbonate transport  
    involved_in bicarbonate transport  
    acts_upstream_of_or_within cerebrospinal fluid secretion PubMed 
    acts_upstream_of_or_within epithelial cell development PubMed 
    involved_in inorganic anion transport  
    acts_upstream_of_or_within mitochondrion distribution PubMed 
    involved_in monoatomic anion transmembrane transport  
    acts_upstream_of_or_within monoatomic ion transport PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    involved_in regulation of intracellular pH  
    acts_upstream_of_or_within regulation of systemic arterial blood pressure PubMed 
    involved_in renal system process  
    acts_upstream_of_or_within renal system process PubMed 
    acts_upstream_of_or_within retina development in camera-type eye PubMed 
    involved_in sodium ion transmembrane transport  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    electrogenic sodium bicarbonate cotransporter 4
    Names
    anion exchange protein
    solute carrier family 4 member 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166067.1NP_001159539.1  electrogenic sodium bicarbonate cotransporter 4

      Status: VALIDATED

      Source sequence(s)
      AC160400, BB398090, BQ175480, BY732178, CA526642, CF725373, CK626530, CK626745, CO424019, CO428205, CO431509, CX562762
      Consensus CDS
      CCDS51819.1
      UniProtKB/TrEMBL
      D3YVG0, D3YX36
      Related
      ENSMUSP00000041007.8, ENSMUST00000039212.8
      Conserved Domains (3) summary
      TIGR00834
      Location:7931
      ae; anion exchange protein
      pfam00955
      Location:365884
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:25292
      Band_3_cyto; Band 3 cytoplasmic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      83184561..83281927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505964.3XP_006506027.1  electrogenic sodium bicarbonate cotransporter 4 isoform X2

      UniProtKB/Swiss-Prot
      E9Q3M5
      Conserved Domains (1) summary
      cl26877
      Location:1261094
      Band_3_cyto; Band 3 cytoplasmic domain
    2. XM_006505965.3XP_006506028.1  electrogenic sodium bicarbonate cotransporter 4 isoform X3

      UniProtKB/Swiss-Prot
      E9Q3M5
      Conserved Domains (1) summary
      cl26877
      Location:1261059
      Band_3_cyto; Band 3 cytoplasmic domain
    3. XM_006505967.3XP_006506030.1  electrogenic sodium bicarbonate cotransporter 4 isoform X5

      UniProtKB/Swiss-Prot
      E9Q3M5
      Related
      ENSMUSP00000109533.2, ENSMUST00000113900.8
      Conserved Domains (1) summary
      cl26877
      Location:1261059
      Band_3_cyto; Band 3 cytoplasmic domain
    4. XM_006505963.4XP_006506026.1  electrogenic sodium bicarbonate cotransporter 4 isoform X1

      UniProtKB/Swiss-Prot
      E9Q3M5
      Conserved Domains (1) summary
      cl26877
      Location:1131174
      Band_3_cyto; Band 3 cytoplasmic domain
    5. XM_006505966.2XP_006506029.1  electrogenic sodium bicarbonate cotransporter 4 isoform X4

      UniProtKB/Swiss-Prot
      E9Q3M5
      Conserved Domains (1) summary
      cl26877
      Location:71059
      Band_3_cyto; Band 3 cytoplasmic domain
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