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    Nrp2 neuropilin 2 [ Mus musculus (house mouse) ]

    Gene ID: 18187, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nrp2provided by MGI
    Official Full Name
    neuropilin 2provided by MGI
    Primary source
    MGI:MGI:1100492
    See related
    Ensembl:ENSMUSG00000025969 AllianceGenome:MGI:1100492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Np2; Np-2; Npn2; Npn-2; 1110048P06Rik
    Summary
    Enables semaphorin receptor activity. Involved in several processes, including nervous system development; outflow tract septum morphogenesis; and ventral trunk neural crest cell migration. Acts upstream of or within several processes, including axon guidance; cellular response to leukemia inhibitory factor; and trunk neural crest cell migration. Located in axon. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and sensory organ. Used to study autism spectrum disorder. Orthologous to human NRP2 (neuropilin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 32.3), limb E14.5 (RPKM 16.1) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nrp2 in Genome Data Viewer
    Location:
    1 C2; 1 31.35 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (62742476..62857851)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (62703317..62818692)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene par-3 family cell polarity regulator beta Neighboring gene STARR-seq mESC enhancer starr_01105 Neighboring gene STARR-seq mESC enhancer starr_01106 Neighboring gene predicted gene, 34881 Neighboring gene STARR-seq mESC enhancer starr_01110 Neighboring gene STARR-seq mESC enhancer starr_01112 Neighboring gene 40S ribosomal protein S2-like Neighboring gene STARR-seq mESC enhancer starr_01115 Neighboring gene STARR-seq mESC enhancer starr_01116 Neighboring gene RIKEN cDNA 4930487H11 gene Neighboring gene predicted gene 29083 Neighboring gene predicted gene, 35120 Neighboring gene predicted gene, 39652 Neighboring gene predicted gene 4208

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding  
    enables identical protein binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables semaphorin receptor activity  
    enables semaphorin receptor activity PubMed 
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in angiogenesis  
    involved_in axon extension involved in axon guidance PubMed 
    involved_in axon guidance  
    acts_upstream_of_or_within axon guidance PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor PubMed 
    involved_in dorsal root ganglion morphogenesis PubMed 
    involved_in facial nerve structural organization PubMed 
    involved_in facioacoustic ganglion development PubMed 
    involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus PubMed 
    acts_upstream_of_or_within heart development PubMed 
    acts_upstream_of_or_within negative chemotaxis PubMed 
    acts_upstream_of_or_within negative chemotaxis PubMed 
    involved_in nerve development PubMed 
    involved_in neural crest cell migration involved in autonomic nervous system development PubMed 
    involved_in neuron migration PubMed 
    involved_in outflow tract septum morphogenesis PubMed 
    involved_in regulation of postsynapse organization PubMed 
    involved_in regulation of postsynapse organization PubMed 
    involved_in semaphorin-plexin signaling pathway PubMed 
    involved_in sensory neuron axon guidance PubMed 
    involved_in sympathetic ganglion development PubMed 
    involved_in sympathetic neuron projection extension PubMed 
    involved_in sympathetic neuron projection guidance PubMed 
    involved_in trigeminal ganglion development PubMed 
    acts_upstream_of_or_within trunk neural crest cell migration PubMed 
    involved_in vascular endothelial growth factor signaling pathway  
    involved_in ventral trunk neural crest cell migration PubMed 
    involved_in vestibulocochlear nerve structural organization PubMed 
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    is_active_in axon  
    located_in axon PubMed 
    is_active_in glutamatergic synapse  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    is_active_in postsynaptic membrane  
    is_active_in postsynaptic membrane PubMed 

    General protein information

    Preferred Names
    neuropilin-2
    Names
    vascular endothelial cell growth factor 165 receptor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077403.1NP_001070871.1  neuropilin-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001070871.1

      Status: VALIDATED

      Source sequence(s)
      AK149643, AK153553, AL671560, BY320114
      Consensus CDS
      CCDS35589.1
      UniProtKB/Swiss-Prot
      B1AT44, O35373, O35374, O35375, O35376, O35377, O35378
      Related
      ENSMUSP00000109794.3, ENSMUST00000114157.3
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:849928
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    2. NM_001077404.1NP_001070872.1  neuropilin-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001070872.1

      Status: VALIDATED

      Source sequence(s)
      AK149643, AL671560, BC098200, BY320114
      Consensus CDS
      CCDS35590.1
      UniProtKB/TrEMBL
      Q8QZY7
      Related
      ENSMUSP00000069379.7, ENSMUST00000063594.13
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:844923
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    3. NM_001077405.1NP_001070873.1  neuropilin-2 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AK149643, AK153553, AL671560, BY320114
      Consensus CDS
      CCDS35591.1
      UniProtKB/TrEMBL
      Q3U5I8
      Related
      ENSMUSP00000099886.3, ENSMUST00000102822.9
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:827906
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    4. NM_001077406.1NP_001070874.1  neuropilin-2 isoform 5 precursor

      See identical proteins and their annotated locations for NP_001070874.1

      Status: VALIDATED

      Source sequence(s)
      AK149643, AK153553, AL671560, BY320114
      Consensus CDS
      CCDS35592.1
      UniProtKB/TrEMBL
      Q3U5I8
      Related
      ENSMUSP00000027112.7, ENSMUST00000027112.13
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:822901
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    5. NM_001077407.1NP_001070875.1  neuropilin-2 isoform 6 precursor

      See identical proteins and their annotated locations for NP_001070875.1

      Status: VALIDATED

      Source sequence(s)
      AK149643, AK153553, BY320114
      Consensus CDS
      CCDS35593.1
      UniProtKB/TrEMBL
      Q3U5I8
      Related
      ENSMUSP00000109792.2, ENSMUST00000114155.8
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:817896
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    6. NM_010939.2NP_035069.2  neuropilin-2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_035069.2

      Status: VALIDATED

      Source sequence(s)
      AK149643, AK153553, AL671560, BY320114
      Consensus CDS
      CCDS14995.1
      UniProtKB/TrEMBL
      Q3U5I8
      Related
      ENSMUSP00000074642.6, ENSMUST00000075144.12
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:832911
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      62742476..62857851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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