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    B3gat3 beta-1,3-glucuronyltransferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 72727, updated on 9-Dec-2024

    Summary

    Official Symbol
    B3gat3provided by MGI
    Official Full Name
    beta-1,3-glucuronyltransferase 3provided by MGI
    Primary source
    MGI:MGI:1919977
    See related
    Ensembl:ENSMUSG00000071649 AllianceGenome:MGI:1919977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810405M13Rik
    Summary
    Predicted to enable galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity and protein phosphatase activator activity. Involved in glycosaminoglycan biosynthetic process. Predicted to be located in cis-Golgi network. Predicted to be active in Golgi membrane. Is expressed in several structures, including cranium; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Larsen-like syndrome B3GAT3 type. Orthologous to human B3GAT3 (beta-1,3-glucuronyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 58.2), cerebellum adult (RPKM 55.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See B3gat3 in Genome Data Viewer
    Location:
    19 A; 19 6.03 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8897740..8904600)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8920374..8927236)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:8967434-8967543 Neighboring gene STARR-positive B cell enhancer ABC_E4265 Neighboring gene integrator complex subunit 5 Neighboring gene alpha glucosidase 2 alpha neutral subunit Neighboring gene STARR-seq mESC enhancer starr_45501 Neighboring gene predicted gene, 36629 Neighboring gene echinoderm microtubule associated protein like 3 Neighboring gene rod outer segment membrane protein 1 Neighboring gene predicted gene 10353 Neighboring gene STARR-positive B cell enhancer ABC_E5684 Neighboring gene metastasis-associated gene family, member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process  
    involved_in chondroitin sulfate proteoglycan biosynthetic process  
    acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process  
    involved_in chondroitin sulfate proteoglycan biosynthetic process  
    involved_in chondroitin sulfate proteoglycan biosynthetic process  
    acts_upstream_of_or_within dermatan sulfate proteoglycan biosynthetic process  
    involved_in dermatan sulfate proteoglycan biosynthetic process  
    involved_in dermatan sulfate proteoglycan biosynthetic process  
    involved_in glycosaminoglycan biosynthetic process PubMed 
    involved_in glycosaminoglycan biosynthetic process PubMed 
    involved_in glycosaminoglycan biosynthetic process  
    involved_in glycosaminoglycan biosynthetic process  
    acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process  
    involved_in heparan sulfate proteoglycan biosynthetic process  
    involved_in positive regulation of catalytic activity  
    involved_in positive regulation of catalytic activity  
    involved_in positive regulation of intracellular protein transport  
    involved_in positive regulation of intracellular protein transport  
    involved_in protein glycosylation  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus PubMed 
    located_in Golgi apparatus  
    is_active_in Golgi membrane  
    located_in Golgi membrane  
    located_in cis-Golgi network  
    located_in cis-Golgi network  

    General protein information

    Preferred Names
    galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
    Names
    UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase
    glcAT-I
    glcUAT-I
    glucuronosyltransferase I
    glucuronyltransferase I
    NP_077218.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024256.2NP_077218.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

      See identical proteins and their annotated locations for NP_077218.1

      Status: VALIDATED

      Source sequence(s)
      BC004038
      Consensus CDS
      CCDS29558.1
      UniProtKB/Swiss-Prot
      P58158
      UniProtKB/TrEMBL
      Q3UJY2, Q3UN75
      Related
      ENSMUSP00000093962.6, ENSMUST00000096243.7
      Conserved Domains (1) summary
      cd00218
      Location:75313
      GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8897740..8904600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003952823.2 RNA Sequence

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