Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc8a1provided by MGI
Official Full Name: solute carrier family 8 (sodium/calcium exchanger), member 1provided by MGI
Primary source: MGI:MGI:107956
See related: Ensembl:ENSMUSG00000054640 AllianceGenome:MGI:107956
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ncx1; D930008O12Rik
Summary: Enables ankyrin binding activity; calcium:sodium antiporter activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to caffeine; metal ion transport; and vascular associated smooth muscle contraction. Acts upstream of or within several processes, including embryonic organ development; metal ion transport; and negative regulation of protein serine/threonine kinase activity. Located in several cellular components, including T-tubule; basolateral plasma membrane; and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and nose. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in heart adult (RPKM 10.8), frontal lobe adult (RPKM 7.0) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E3; 17 51.29 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (81680534..82045816, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (81373105..81738387, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1.
Title: Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1.
Silencing mouse circular RNA circSlc8a1 by circular antisense cA-circSlc8a1 induces cardiac hepatopathy.
Title: Silencing mouse circular RNA circSlc8a1 by circular antisense cA-circSlc8a1 induces cardiac hepatopathy.
Higher Na(+)-Ca(2+) Exchanger Function and Triggered Activity Contribute to Male Predisposition to Atrial Fibrillation.
Title: Higher Na(+)-Ca(2+) Exchanger Function and Triggered Activity Contribute to Male Predisposition to Atrial Fibrillation.
IN BRAIN POST-ISCHEMIC PLASTICITY, Na(+)/Ca(2+) EXCHANGER 1 AND Ascl1 INTERVENE IN MICROGLIA-DEPENDENT CONVERSION OF ASTROCYTES INTO NEURONAL LINEAGE.
Title: IN BRAIN POST-ISCHEMIC PLASTICITY, Na(+)/Ca(2+) EXCHANGER 1 AND Ascl1 INTERVENE IN MICROGLIA-DEPENDENT CONVERSION OF ASTROCYTES INTO NEURONAL LINEAGE.
Na(+)/Ca(2+) exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons.
Title: Na(+)/Ca(2+) exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons.
Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia.
Title: Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia.
Genetic knockout and pharmacologic inhibition of NCX1 attenuate hypoxia-induced pulmonary arterial hypertension.
Title: Genetic knockout and pharmacologic inhibition of NCX1 attenuate hypoxia-induced pulmonary arterial hypertension.
Genetic Up-Regulation or Pharmacological Activation of the Na(+)/Ca(2+) Exchanger 1 (NCX1) Enhances Hippocampal-Dependent Contextual and Spatial Learning and Memory.
Title: Genetic Up-Regulation or Pharmacological Activation of the Na(+)/Ca(2+) Exchanger 1 (NCX1) Enhances Hippocampal-Dependent Contextual and Spatial Learning and Memory.
NO-induced vasodilation correlates directly with BP in smooth muscle-Na/Ca exchanger-1-engineered mice: elevated BP does not attenuate endothelial function.
Title: NO-induced vasodilation correlates directly with BP in smooth muscle-Na/Ca exchanger-1-engineered mice: elevated BP does not attenuate endothelial function.
NCX1 is able to sense Na+ and is required for amplifying inflammatory and antimicrobial macrophage responses upon high salt exposure.
Title: NCX1 represents an ionic Na+ sensing mechanism in macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (81)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc8a1 (e-PCR), detects polymorphism
- UniSTS:265748

PMC20271P1 (e-PCR)
- UniSTS:271894

D17Mit243 (e-PCR), detects polymorphism
- UniSTS:128055

D6Wox29 (e-PCR)
- UniSTS:240447

AI605517 (e-PCR)
- UniSTS:181068

AI852629 (e-PCR)
- UniSTS:181069

UniSTS:239208 (e-PCR)
- UniSTS:239208

Slc8a1 (e-PCR), detects polymorphism
- UniSTS:239208

Slc8a1 (e-PCR), detects polymorphism
- UniSTS:243332

NoName (e-PCR)
- UniSTS:237714

Slc8a1 (e-PCR), detects polymorphism
- UniSTS:532894

SLC8A1 (e-PCR), detects polymorphism
- UniSTS:480166

Slc8a1 (e-PCR), detects polymorphism
- UniSTS:527553

NoName (e-PCR)
- UniSTS:484033

RH141979 (e-PCR)
- UniSTS:223970

RH136155 (e-PCR)
- UniSTS:210150

RH141999 (e-PCR)
- UniSTS:223990

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ankyrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
enables calcium:sodium antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium:sodium antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium:sodium antiporter activity	ISO Inferred from Sequence Orthology more info
enables calcium:sodium antiporter activity	TAS Traceable Author Statement more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion export	ISO Inferred from Sequence Orthology more info
involved_in calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in calcium ion transport into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell communication	IEA Inferred from Electronic Annotation more info
involved_in cell communication by electrical coupling involved in cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to caffeine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell membrane potential	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of the force of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in relaxation of smooth muscle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ATP	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to muscle stretch	ISO Inferred from Sequence Orthology more info
involved_in sodium ion export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in vascular associated smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/calcium exchanger 1

Names: Na(+)/Ca(2+)-exchange protein 1; Na/Ca exchanger; solute carrier family 8 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112798.2 → NP_001106269.1 sodium/calcium exchanger 1 isoform B precursor

See identical proteins and their annotated locations for NP_001106269.1

Status: VALIDATED

Description

Transcript Variant: This variant (B) lacks two in-frame exons in the coding region, compared to variant A. The resulting isoform (B) lacks two internal segments, compared to isoform A.

Source sequence(s)

AC122399, BB660129, BC079673

Consensus CDS

CCDS50191.1

UniProtKB/TrEMBL

G5E8Y0, Q68FL0

Related

ENSMUSP00000157278.2, ENSMUST00000234131.2

Conserved Domains (1) summary

TIGR00845
Location:1 → 958

caca; sodium/calcium exchanger 1
NM_001286684.1 → NP_001273613.1 sodium/calcium exchanger 1 isoform C precursor

See identical proteins and their annotated locations for NP_001273613.1

Status: VALIDATED

Description

Transcript Variant: This variant (C) lacks an internal segment in the 3' terminal exon, which results in an alternate stop codon, compared to variant A. The resulting isoform (C) has a shorter and distinct C-terminus, compared to isoform A.

Source sequence(s)

AC104139, AC122399, AC131656

Consensus CDS

CCDS89163.1

UniProtKB/TrEMBL

A0A3Q4EBU5, O35157

Related

ENSMUSP00000157030.2, ENSMUST00000235015.2

Conserved Domains (5) summary

smart00237
Location:534 → 624

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

TIGR00845
Location:1 → 935

caca; sodium/calcium exchanger 1

pfam01699
Location:797 → 928

Na_Ca_ex; Sodium/calcium exchanger protein

pfam03160
Location:403 → 493

Calx-beta; Calx-beta domain

pfam16494
Location:251 → 381

Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
NM_011406.3 → NP_035536.2 sodium/calcium exchanger 1 isoform A precursor

See identical proteins and their annotated locations for NP_035536.2

Status: VALIDATED

Description

Transcript Variant: This variant (A) encodes the longest isoform (A).

Source sequence(s)

AC122399, BB660129, BC079673, U70033

Consensus CDS

CCDS37706.1

UniProtKB/Swiss-Prot

P70414

UniProtKB/TrEMBL

G3X9J1

Related

ENSMUSP00000132809.3, ENSMUST00000163123.3

Conserved Domains (1) summary

TIGR00845
Location:1 → 970

caca; sodium/calcium exchanger 1

RNA

NR_104580.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (D) differs in several internal exons, compared to variant A. This variant is represented as non-coding because the use of the 5'-most expected translation start codon, as used in variant A, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC104139, AC122399, AC131656

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

81680534..82045816 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523933.3 → XP_006523996.1 sodium/calcium exchanger 1 isoform X1

See identical proteins and their annotated locations for XP_006523996.1

UniProtKB/Swiss-Prot

P70414

UniProtKB/TrEMBL

G3X9J1

Conserved Domains (1) summary

TIGR00845
Location:1 → 970

caca; sodium/calcium exchanger 1
XM_006523944.2 → XP_006524007.1 sodium/calcium exchanger 1 isoform X12

UniProtKB/TrEMBL

G5E8Y0

Conserved Domains (1) summary

TIGR00845
Location:1 → 934

caca; sodium/calcium exchanger 1
XM_006523940.2 → XP_006524003.1 sodium/calcium exchanger 1 isoform X8

UniProtKB/TrEMBL

G5E8Y0

Conserved Domains (1) summary

TIGR00845
Location:1 → 957

caca; sodium/calcium exchanger 1
XM_006523938.2 → XP_006524001.1 sodium/calcium exchanger 1 isoform X6

UniProtKB/TrEMBL

G5E8Y0

Conserved Domains (1) summary

TIGR00845
Location:1 → 962

caca; sodium/calcium exchanger 1
XM_006523942.2 → XP_006524005.1 sodium/calcium exchanger 1 isoform X10

UniProtKB/Swiss-Prot

P70414

Conserved Domains (1) summary

TIGR00845
Location:1 → 941

caca; sodium/calcium exchanger 1
XM_006523936.2 → XP_006523999.1 sodium/calcium exchanger 1 isoform X4

UniProtKB/Swiss-Prot

P70414

Conserved Domains (1) summary

TIGR00845
Location:1 → 964

caca; sodium/calcium exchanger 1
XM_006523934.2 → XP_006523997.1 sodium/calcium exchanger 1 isoform X2

UniProtKB/Swiss-Prot

P70414

Conserved Domains (1) summary

TIGR00845
Location:1 → 969

caca; sodium/calcium exchanger 1
XM_006523943.2 → XP_006524006.1 sodium/calcium exchanger 1 isoform X11

UniProtKB/TrEMBL

G5E8Y0

Conserved Domains (1) summary

TIGR00845
Location:1 → 935

caca; sodium/calcium exchanger 1
XM_006523939.2 → XP_006524002.1 sodium/calcium exchanger 1 isoform X7

See identical proteins and their annotated locations for XP_006524002.1

UniProtKB/TrEMBL

G5E8Y0, Q68FL0

Conserved Domains (1) summary

TIGR00845
Location:1 → 958

caca; sodium/calcium exchanger 1
XM_006523937.2 → XP_006524000.1 sodium/calcium exchanger 1 isoform X5

UniProtKB/TrEMBL

G5E8Y0

Related

ENSMUSP00000126373.3, ENSMUST00000163680.9

Conserved Domains (1) summary

TIGR00845
Location:1 → 963

caca; sodium/calcium exchanger 1
XM_006523941.2 → XP_006524004.1 sodium/calcium exchanger 1 isoform X9

UniProtKB/Swiss-Prot

P70414

Conserved Domains (1) summary

TIGR00845
Location:1 → 942

caca; sodium/calcium exchanger 1
XM_006523935.2 → XP_006523998.1 sodium/calcium exchanger 1 isoform X3

UniProtKB/Swiss-Prot

P70414

Conserved Domains (1) summary

TIGR00845
Location:1 → 965

caca; sodium/calcium exchanger 1
XM_006523932.2 → XP_006523995.1 sodium/calcium exchanger 1 isoform X1

See identical proteins and their annotated locations for XP_006523995.1

UniProtKB/Swiss-Prot

P70414

UniProtKB/TrEMBL

G3X9J1

Conserved Domains (1) summary

TIGR00845
Location:1 → 970

caca; sodium/calcium exchanger 1
XM_017317368.2 → XP_017172857.1 sodium/calcium exchanger 1 isoform X13

UniProtKB/TrEMBL

Q27PY9, Q91ZJ7

Conserved Domains (1) summary

TIGR00845
Location:1 → 639

caca; sodium/calcium exchanger 1
XM_017317369.2 → XP_017172858.1 sodium/calcium exchanger 1 isoform X13

UniProtKB/TrEMBL

Q27PY9, Q91ZJ7

Related

ENSMUSP00000159714.1, ENSMUST00000249357.1

Conserved Domains (1) summary

TIGR00845
Location:1 → 639

caca; sodium/calcium exchanger 1
XM_017317370.2 → XP_017172859.1 sodium/calcium exchanger 1 isoform X13

UniProtKB/TrEMBL

Q27PY9, Q91ZJ7

Conserved Domains (1) summary

TIGR00845
Location:1 → 639

caca; sodium/calcium exchanger 1