Rbpjl recombination signal binding protein for immunoglobulin kappa J region-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbpjlprovided by MGI
Official Full Name: recombination signal binding protein for immunoglobulin kappa J region-likeprovided by MGI
Primary source: MGI:MGI:1196616
See related: Ensembl:ENSMUSG00000017007 AllianceGenome:MGI:1196616
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RBP-L; Rbpsuhl
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of DNA-templated transcription. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including foregut-midgut junction; genitourinary system; limb mesenchyme; lung; and neural tube. Orthologous to human RBPJL (recombination signal binding protein for immunoglobulin kappa J region like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in lung adult (RPKM 40.4), small intestine adult (RPKM 29.8) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 85.16 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164244996..164257368)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (164403081..164415448)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Directed pancreatic acinar differentiation of mouse embryonic stem cells via embryonic signalling molecules and exocrine transcription factors.
Title: Directed pancreatic acinar differentiation of mouse embryonic stem cells via embryonic signalling molecules and exocrine transcription factors.
Notch1/RBP-J signaling induces expression of key transcriptional regulators involved in cell lineage determination in the absence of protein synthesis
Title: Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors.
Replacement of Rbpj by Rbpjl in the PTF1 complex drives acinar differentiation by maximizing secretory protein synthesis.
Title: Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.
During pancreatic acinar development, Rbpjl replaces Rbpj in the PTF1 complex residing on active acinar specific promoters.
Title: Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.
RBPJL is the third subunit of an unusual bHLH factor complex that binds and activates pancreatic acinar specific genes
Title: PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y10926 (e-PCR)
- UniSTS:178767

Rbpjl (e-PCR), detects polymorphism
- UniSTS:525509

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: recombining binding protein suppressor of hairless-like protein

Names: RBP-J kappa-like; transcription factor RBP-L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009036.1 → NP_033062.1 recombining binding protein suppressor of hairless-like protein

See identical proteins and their annotated locations for NP_033062.1

Status: PROVISIONAL

Source sequence(s)

Y10926

Consensus CDS

CCDS17035.1

UniProtKB/Swiss-Prot

O08674

UniProtKB/TrEMBL

Q3V2I2

Related

ENSMUSP00000017151.2, ENSMUST00000017151.2

Conserved Domains (3) summary

cd01176
Location:379 → 475

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:205 → 357

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:67 → 203

LAG1-DNAbind; LAG1, DNA binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

164244996..164257368

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248825.2 → XP_030104685.1 recombining binding protein suppressor of hairless-like protein isoform X2

Conserved Domains (2) summary

pfam09270
Location:205 → 250

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:67 → 199

LAG1-DNAbind; LAG1, DNA binding
XM_036159748.1 → XP_036015641.1 recombining binding protein suppressor of hairless-like protein isoform X1

Conserved Domains (3) summary

cd01176
Location:276 → 372

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:129 → 254

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:1 → 96

LAG1-DNAbind; LAG1, DNA binding