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    Sbk1 SH3-binding kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 104175, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sbk1provided by MGI
    Official Full Name
    SH3-binding kinase 1provided by MGI
    Primary source
    MGI:MGI:2135937
    See related
    Ensembl:ENSMUSG00000042978 AllianceGenome:MGI:2135937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sbk
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SBK1 (SH3 domain binding kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 125.5), CNS E14 (RPKM 100.4) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sbk1 in Genome Data Viewer
    Location:
    7 F3; 7 69.01 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (125847524..125894188)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126248397..126295016)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20132 Neighboring gene STARR-seq mESC enhancer starr_20133 Neighboring gene RIKEN cDNA 1700123J17 gene Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20134 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133373927-133374110 Neighboring gene STARR-seq mESC enhancer starr_20135 Neighboring gene STARR-seq mESC enhancer starr_20136 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133415262-133415415 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133428849-133429094 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20139 Neighboring gene predicted gene, 30928

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential regulation of hepatic SH3 domain binding kinase 1 (SBK1) expression in mouse and goldfish. Hang M, et al. Gen Comp Endocrinol, 2023 Dec 1. PMID 37652166
    2. Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway. Ahuja P, et al. Hepatology, 2023 Jan 1. PMID 35363898
    3. Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain. Nara K, et al. Eur J Biochem, 2001 May. PMID 11322885
    4. The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. Schilling K, et al. Cerebellum, 2009 Dec. PMID 19554387
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential regulation of hepatic SH3 domain binding kinase 1 (SBK1) expression in mouse and goldfish.
      Title: Differential regulation of hepatic SH3 domain binding kinase 1 (SBK1) expression in mouse and goldfish.
    2. Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway.
      Title: Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase SBK1
    Names
    SH3 domain-binding kinase 1
    NP_001347740.1
    NP_001390491.1
    NP_663562.1
    XP_036008449.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360811.2 → NP_001347740.1  serine/threonine-protein kinase SBK1

      Status: VALIDATED

      Source sequence(s)
      AC135809
      Consensus CDS
      CCDS21824.1
      UniProtKB/Swiss-Prot
      Q8QZX0
      UniProtKB/TrEMBL
      A0A0B6VRD5
      Related
      ENSMUSP00000159131.2, ENSMUST00000239081.2
      Conserved Domains (1) summary
      cd13987
      Location:59 → 317
      STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1

    2. NM_001403562.1 → NP_001390491.1  serine/threonine-protein kinase SBK1

      Status: VALIDATED

      Source sequence(s)
      AC135809
      UniProtKB/Swiss-Prot
      Q8QZX0
      UniProtKB/TrEMBL
      A0A0B6VRD5

    3. NM_145587.4 → NP_663562.1  serine/threonine-protein kinase SBK1

      See identical proteins and their annotated locations for NP_663562.1

      Status: VALIDATED

      Source sequence(s)
      AC135809
      Consensus CDS
      CCDS21824.1
      UniProtKB/Swiss-Prot
      Q8QZX0
      UniProtKB/TrEMBL
      A0A0B6VRD5
      Related
      ENSMUSP00000060907.10, ENSMUST00000056028.11
      Conserved Domains (1) summary
      cd13987
      Location:59 → 317
      STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      125847524..125894188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152556.1 → XP_036008449.1  serine/threonine-protein kinase SBK1 isoform X1

      UniProtKB/TrEMBL
      A0A0B6VRD5
      Conserved Domains (1) summary
      cd13987
      Location:67 → 325
      STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8QZX0.1 GenPept UniProtKB/Swiss-Prot:Q8QZX0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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