LGALS12 galectin 12 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LGALS12provided by HGNC
Official Full Name: galectin 12provided by HGNC
Primary source: HGNC:HGNC:15788
See related: Ensembl:ENSG00000133317 MIM:606096; AllianceGenome:HGNC:15788
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GAL12; GRIP1
Summary: This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
Expression: Biased expression in fat (RPKM 41.6) and bone marrow (RPKM 4.0) See more
Orthologs: mouse all
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Genomic context

Location:: 11q12.3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (63506084..63516772)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (63495347..63506035)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (63273556..63284244)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression and secretion of galectin-12 in the context of neutrophilic differentiation of human promyeloblastic HL-60 cells.
Title: Expression and secretion of galectin-12 in the context of neutrophilic differentiation of human promyeloblastic HL-60 cells.
Placental expression of inflammatory Galectin-12 is associated with gestational diabetes.
Title: Placental expression of inflammatory Galectin-12 is associated with gestational diabetes.
Galectin-12 in Pancreatic Cancer: A New Player in the Microenvironment?
Title: Galectin-12 in Pancreatic Cancer: A New Player in the Microenvironment?
Ablation of Galectin-12 Inhibits Atherosclerosis through Enhancement of M2 Macrophage Polarization.
Title: Ablation of Galectin-12 Inhibits Atherosclerosis through Enhancement of M2 Macrophage Polarization.
that binding of galectin-12 to SLC1A5 significantly reduced glutamine uptake
Title: Deciphering the galectin-12 protein interactome reveals a major impact of galectin-12 on glutamine anaplerosis in colon cancer cells.
Galectin-12 is silenced in colorectal cancer via hypermethylation of its promoter.
Title: Analyzing epigenetic control of galectin expression indicates silencing of galectin-12 by promoter methylation in colorectal cancer.
Overexpression of galectin-12 contributes to a differentiation block in acute promyelocytic leukemia cells, and suppression of galectin-12 facilitates granulocytic differentiation.
Title: Galectin-12 inhibits granulocytic differentiation of human NB4 promyelocytic leukemia cells while promoting lipogenesis.
Lower LGALS12 gene expression is associated with acute myeloid leukemia.
Title: Expression profiling of cancer-related galectins in acute myeloid leukemia.
results suggest that mouse galectin-12 is a major regulator of adipose tissue development
Title: Galectin-12 is required for adipogenic signaling and adipocyte differentiation.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables lactose binding	IBA Inferred from Biological aspect of Ancestor more info
enables lactose binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galectin-12

Names: galectin-related inhibitor of proliferation; lectin, galactoside-binding, soluble, 12; testicular secretory protein Li 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.