Npy neuropeptide Y [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npyprovided by MGI
Official Full Name: neuropeptide Yprovided by MGI
Primary source: MGI:MGI:97374
See related: Ensembl:ENSMUSG00000029819 AllianceGenome:MGI:97374
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0710005A05Rik
Summary: This gene encodes a neuropeptide that plays a pivotal role in many physiological functions such as food intake, energy homeostasis, circadian rhythm, and cognition. The encoded protein precursor undergoes proteolytic processing to generate the biologically active peptide. Mice lacking the encoded protein exhibit mild seizures occasionally and become hyperphagic following food deprivation. A deficiency of the encoded protein partially prevents mice lacking leptin from becoming obese. [provided by RefSeq, Oct 2015]
Expression: Biased expression in adrenal adult (RPKM 214.2), frontal lobe adult (RPKM 128.9) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B2.3; 6 24.04 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (49799690..49806487)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (49822710..49829507)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sympathetic neuropeptide Y protects from obesity by sustaining thermogenic fat.
Title: Sympathetic neuropeptide Y protects from obesity by sustaining thermogenic fat.
NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation.
Title: NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation.
The plasticity of neuropeptide Y-Y1 receptor system on Tac2 neurons contributes to mechanical hyperknesis during chronic itch.
Title: The plasticity of neuropeptide Y-Y1 receptor system on Tac2 neurons contributes to mechanical hyperknesis during chronic itch.
Important role of NPY-Y4R signalling in the dual control of feeding and physical activity.
Title: Important role of NPY-Y4R signalling in the dual control of feeding and physical activity.
Regulation of colonic neuropeptide Y expression by the gut microbiome in patients with ulcerative colitis and its association with anxiety- and depression-like behavior in mice.
Title: Regulation of colonic neuropeptide Y expression by the gut microbiome in patients with ulcerative colitis and its association with anxiety- and depression-like behavior in mice.
Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity.
Title: Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity.
Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1.
Title: Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1.
Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling.
Title: Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling.
Neuropeptide Y in the medial habenula alleviates migraine-like behaviors through the Y1 receptor.
Title: Neuropeptide Y in the medial habenula alleviates migraine-like behaviors through the Y1 receptor.
Deficiency of neuropeptide Y attenuates neointima formation after vascular injury in mice.
Title: Deficiency of neuropeptide Y attenuates neointima formation after vascular injury in mice.

Submit: New GeneRIF Correction See all GeneRIFs (194)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Npy (e-PCR), detects polymorphism
- UniSTS:527457

NoName (e-PCR)
- UniSTS:548462

Npy (e-PCR), detects polymorphism
- UniSTS:144064

D4Wox21 (e-PCR)
- UniSTS:117977

D6Kyo1 (e-PCR), detects polymorphism
- UniSTS:117977

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor binding	IGI Inferred from Genetic Interaction more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide Y receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide Y receptor binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adult feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in adult feeding behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antifungal humoral response	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in central nervous system neuron development	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in monocyte activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of acute inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of appetite	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dopamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of eating behavior	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of nerve growth factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in response to yeast	ISO Inferred from Sequence Orthology more info
involved_in synaptic signaling via neuropeptide	EXP Inferred from Experiment more info	PubMed
involved_in synaptic signaling via neuropeptide	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
located_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
located_in neuronal dense core vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pro-neuropeptide Y

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.