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    Kera keratocan [ Mus musculus (house mouse) ]

    Gene ID: 16545, updated on 9-Dec-2024

    Summary

    Official Symbol
    Keraprovided by MGI
    Official Full Name
    keratocanprovided by MGI
    Primary source
    MGI:MGI:1202398
    See related
    Ensembl:ENSMUSG00000019932 AllianceGenome:MGI:1202398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KTN; CNA2; SLRR2B
    Summary
    Acts upstream of or within cornea development in camera-type eye. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; connective tissue; jaw; limb; and sensory organ. Used to study cornea plana. Human ortholog(s) of this gene implicated in arcus senilis; cornea plana; and corneal dystrophy. Orthologous to human KERA (keratocan). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward limb E14.5 (RPKM 43.4) See more
    Orthologs
    NEW
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    Genomic context

    See Kera in Genome Data Viewer
    Location:
    10 C3; 10 50.34 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (97442873..97449555)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (97606962..97613688)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930473O22 gene Neighboring gene lumican Neighboring gene predicted gene, 40749 Neighboring gene epiphycan Neighboring gene predicted gene 10754

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in extracellular region  
    is_active_in extracellular space  

    General protein information

    Preferred Names
    keratocan
    Names
    keratan sulfate proteoglycan keratocan

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008438.3NP_032464.1  keratocan precursor

      See identical proteins and their annotated locations for NP_032464.1

      Status: VALIDATED

      Source sequence(s)
      AC159710
      Consensus CDS
      CCDS36044.1
      UniProtKB/Swiss-Prot
      O35367
      UniProtKB/TrEMBL
      A4FUJ3, Q8C3D9
      Related
      ENSMUSP00000100923.3, ENSMUST00000105286.4
      Conserved Domains (3) summary
      PRK15370
      Location:16298
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:7497
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:268331
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      97442873..97449555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513273.5XP_006513336.1  keratocan isoform X1

      See identical proteins and their annotated locations for XP_006513336.1

      UniProtKB/Swiss-Prot
      O35367
      UniProtKB/TrEMBL
      A4FUJ3, Q8C3D9
      Conserved Domains (3) summary
      PRK15370
      Location:16298
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:7497
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:268331
      LRR_8; Leucine rich repeat
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