Asgr1 asialoglycoprotein receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asgr1provided by MGI
Official Full Name: asialoglycoprotein receptor 1provided by MGI
Primary source: MGI:MGI:88081
See related: Ensembl:ENSMUSG00000020884 AllianceGenome:MGI:88081
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Asgr; HL-1; ASGPR1; Asgr-1
Summary: Enables identical protein binding activity. Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including genitourinary system; heart; intestine; liver; and lung. Orthologous to human ASGR1 (asialoglycoprotein receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 70.2) and liver E18 (RPKM 23.8) See more
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Genomic context

Location:: 11 B3; 11 42.98 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69939735..69948721)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70048909..70057895)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress.
Title: Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress.
ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity.
Title: ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity.
ASGR1 promotes liver injury in sepsis by modulating monocyte-to-macrophage differentiation via NF-kappaB/ATF5 pathway.
Title: ASGR1 promotes liver injury in sepsis by modulating monocyte-to-macrophage differentiation via NF-κB/ATF5 pathway.
Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression.
Title: Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression.
the key roles of the ManR and ASGR in controlling circulating levels of numerous glycoproteins critical for regulating reproductive hormones and blood coagulation.
Title: Functional Consequences of Mannose and Asialoglycoprotein Receptor Ablation.
Mice lacking the hepatocyte asialoglycoprotein receptor are more susceptible to the induction of T cell-mediated hepatitis suggesting a potentially significant role of the ASGPR in the homeostatic regulation of T cells in the liver.
Title: Susceptibility to T cell-mediated liver injury is enhanced in asialoglycoprotein receptor-deficient mice.
found that the asialoglycoprotein receptor (ASGPR) is involved in hepatocyte recognition of cells predestined for killing, including activated autologous T lymphocytes
Title: Hepatocyte cytotoxicity is facilitated by asialoglycoprotein receptor.
Asialoglycoprotein receptor 1 is a novel important factor that responds to endogenous lectins in the tumor microenvironment to promote metastasis by activating the epidermal growth factor receptor-extracellular signal-regulated kinase pathway.
Title: Asialoglycoprotein receptor promotes cancer metastasis by activating the EGFR-ERK pathway.
Proper ASGP receptor function protects against carbon tetrachloride-induced liver damage in a knockout mouse model lacking functional ASGP receptor.
Title: Carbon tetrachloride-induced liver damage in asialoglycoprotein receptor-deficient mice.
ERManI is required for trimming to Man(5-6)GlcNAc(2) and for endoplasmic reticulum associated degradation in cells in vivo.
Title: Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-mannose binding	IBA Inferred from Biological aspect of Ancestor more info
enables asialoglycoprotein receptor activity	IEA Inferred from Electronic Annotation more info
enables asialoglycoprotein receptor activity	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables fucose binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: asialoglycoprotein receptor 1

Names: hepatic lectin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291131.1 → NP_001278060.1 asialoglycoprotein receptor 1 isoform a

See identical proteins and their annotated locations for NP_001278060.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AK132959, AL596185

Consensus CDS

CCDS24933.1

UniProtKB/Swiss-Prot

P34927, Q64363, Q91Y84

Related

ENSMUSP00000121842.3, ENSMUST00000146411.9

Conserved Domains (2) summary

cd03590
Location:153 → 278

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:15 → 143

Lectin_N; Hepatic lectin, N-terminal domain
NM_001291132.1 → NP_001278061.1 asialoglycoprotein receptor 1 isoform b

See identical proteins and their annotated locations for NP_001278061.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.

Source sequence(s)

AK132959, AL596185

Consensus CDS

CCDS70224.1

UniProtKB/TrEMBL

B1AR34

Related

ENSMUSP00000104226.3, ENSMUST00000108585.9

Conserved Domains (2) summary

cd03590
Location:124 → 249

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:15 → 118

Lectin_N; Hepatic lectin, N-terminal domain
NM_009714.3 → NP_033844.1 asialoglycoprotein receptor 1 isoform a

See identical proteins and their annotated locations for NP_033844.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.

Source sequence(s)

AK132959, AL596185

Consensus CDS

CCDS24933.1

UniProtKB/Swiss-Prot

P34927, Q64363, Q91Y84

Related

ENSMUSP00000018699.7, ENSMUST00000018699.13

Conserved Domains (2) summary

cd03590
Location:153 → 278

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:15 → 143

Lectin_N; Hepatic lectin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69939735..69948721

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314231.1 → XP_017169720.1 asialoglycoprotein receptor 1 isoform X1

UniProtKB/Swiss-Prot

P34927, Q64363, Q91Y84

Conserved Domains (2) summary

cd03590
Location:153 → 278

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:15 → 143

Lectin_N; Hepatic lectin, N-terminal domain
XM_036156250.1 → XP_036012143.1 asialoglycoprotein receptor 1 isoform X1

UniProtKB/Swiss-Prot

P34927, Q64363, Q91Y84

Conserved Domains (2) summary

cd03590
Location:153 → 278

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:15 → 143

Lectin_N; Hepatic lectin, N-terminal domain