Prm3 protamine 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prm3provided by MGI
Official Full Name: protamine 3provided by MGI
Primary source: MGI:MGI:106601
See related: Ensembl:ENSMUSG00000050058 AllianceGenome:MGI:106601
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PX; Pxg
Summary: Predicted to enable DNA binding activity. Acts upstream of or within flagellated sperm motility. Located in cytoplasm. Orthologous to human PRM3 (protamine 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 5.84 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (10608372..10608778, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (10790508..10790914, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRM3 shows several clear differences from other protamines, and it cannot be regarded as a true protamine. Among 10 mouse species, PRM3 showed weak evidence of positive selection in two species but no clear association with levels of sperm competition.
Title: Protamine 3 shows evidence of weak, positive selection in mouse species (genus Mus)--but it is not a protamine.
PRM3 is an acidic protein that is localized in the cytoplasm of elongated spermatids. Sperm from Prm3(-/-) males exhibited reductions in motility.
Title: Prm3, the fourth gene in the mouse protamine gene cluster, encodes a conserved acidic protein that affects sperm motility.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

X14004 (e-PCR)
- UniSTS:160522

UniSTS:498766 (e-PCR)
- UniSTS:498766

Prm2 (e-PCR), detects polymorphism
- UniSTS:498766

AI528784 (e-PCR)
- UniSTS:180862

Prm2 (e-PCR), detects polymorphism
- UniSTS:526979

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of nucleosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protamine-3

Names: sperm protamine P3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.