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    Sntg1 syntrophin, gamma 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500394, updated on 4-Jan-2025

    Summary

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    Symbol
    Sntg1provided by RGD
    Full Name
    syntrophin, gamma 1provided by RGD
    Primary source
    RGD:1560290
    See related
    EnsemblRapid:ENSRNOG00000007294 AllianceGenome:RGD:1560290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560290
    Summary
    Predicted to enable actin binding activity and structural molecule activity. Predicted to be located in cytoplasm; cytoskeleton; and ruffle membrane. Predicted to be part of dystrophin-associated glycoprotein complex. Orthologous to human SNTG1 (syntrophin gamma 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 58.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sntg1 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (14769290..15583468)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9980550..10794666)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (10118901..10493094)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase, iron containing, 1 Neighboring gene ribosome biogenesis regulator 1 homolog Neighboring gene transformer 2 alpha, pseudogene 3 Neighboring gene U6 spliceosomal RNA Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 5 Neighboring gene kinesin family member 1C, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization. Hogan A, et al. J Biol Chem, 2004 Dec 17. PMID 15485858
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dystrophin-associated glycoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gamma-1-syntrophin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411862.1 → NP_001398791.1  gamma-1-syntrophin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZSX2, F1M2M1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      14769290..15583468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288183.1 → XP_063144253.1  gamma-1-syntrophin isoform X6

      UniProtKB/TrEMBL
      F1M2M1
      Related
      ENSRNOP00000081625.2, ENSRNOT00000095256.2

    2. XM_063288182.1 → XP_063144252.1  gamma-1-syntrophin isoform X5

      UniProtKB/TrEMBL
      F1M2M1
      Related
      ENSRNOP00000103582.1, ENSRNOT00000153454.1

    3. XM_063288181.1 → XP_063144251.1  gamma-1-syntrophin isoform X5

      UniProtKB/TrEMBL
      F1M2M1

    4. XM_063288179.1 → XP_063144249.1  gamma-1-syntrophin isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZSX2, F1M2M1
      Related
      ENSRNOP00000009679.9, ENSRNOT00000009679.9

    5. XM_039110528.2 → XP_038966456.1  gamma-1-syntrophin isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZSX2, F1M2M1
      Conserved Domains (2) summary
      smart00233
      Location:284 → 389
      PH; Pleckstrin homology domain
      cd00992
      Location:55 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    6. XM_063288180.1 → XP_063144250.1  gamma-1-syntrophin isoform X4

      UniProtKB/TrEMBL
      F1M2M1

    7. XM_063288184.1 → XP_063144254.1  gamma-1-syntrophin isoform X7

    8. XM_063288178.1 → XP_063144248.1  gamma-1-syntrophin isoform X2

      UniProtKB/TrEMBL
      F1M2M1

    9. XM_063288176.1 → XP_063144246.1  gamma-1-syntrophin isoform X1

      UniProtKB/TrEMBL
      F1M2M1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191981.1: Suppressed sequence

      Description
      NM_001191981.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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