F7 coagulation factor VII [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: F7provided by RGD
Official Full Name: coagulation factor VIIprovided by RGD
Primary source: RGD:628678
See related: EnsemblRapid:ENSRNOG00000032737 AllianceGenome:RGD:628678
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables endopeptidase activity and signaling receptor binding activity. Involved in several processes, including response to cholesterol; response to genistein; and response to thyroxine. Located in extracellular space and vesicle. Used to study asthma; diabetes mellitus; and type 2 diabetes mellitus. Biomarker of several diseases, including bilirubin metabolic disorder; familial hyperlipidemia; hypertension; hypothyroidism; and prothrombin deficiency. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebral infarction; diabetes mellitus (multiple); factor VII deficiency; and obesity. Orthologous to human F7 (coagulation factor VII). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 424.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (83191896..83202775, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (76489775..76500636, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (81824610..81834923, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The EGF(1) region of rat coagulation factor can mediate the specific binding of FVII with tissue factor.
Title: [Expression of fusion protein encoding EGFP-EGF1 of rat coagulation factor VII and its binding function].
Inhibition of the proteolytic activity of TF-FVIIa complex blunted hematogenous hepatic metastasis.
Title: Inhibition of tissue factor-factor VIIa proteolytic activity blunts hepatic metastasis in colorectal cancer.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
contributes_to serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood coagulation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of leukocyte chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of leukocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to 2,3,7,8-tetrachlorodibenzodioxine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to Thyroid stimulating hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to astaxanthin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to carbon dioxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cholesterol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to genistein	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to thyroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to thyrotropin-releasing hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to thyroxine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin K	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
part_of serine-type peptidase complex	ISO Inferred from Sequence Orthology more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: coagulation factor VII

Names: serum prothrombin conversion accelerator

NP_690059.1

EC 3.4.21.21

XP_038950167.1

EC 3.4.21.21

XP_038950168.1

EC 3.4.21.21

XP_038950169.1

EC 3.4.21.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152846.2 → NP_690059.1 coagulation factor VII precursor

See identical proteins and their annotated locations for NP_690059.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q8K3U6

UniProtKB/TrEMBL

A6IWK3

Related

ENSRNOP00000038466.1, ENSRNOT00000037806.4

Conserved Domains (3) summary

smart00069
Location:25 → 85

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:87 → 123

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:194 → 430

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

83191896..83202775 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094239.2 → XP_038950167.1 coagulation factor VII isoform X1

UniProtKB/TrEMBL

A6IWK3

Conserved Domains (2) summary

cd00054
Location:71 → 107

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:178 → 414

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_039094241.2 → XP_038950169.1 coagulation factor VII isoform X3

Conserved Domains (3) summary

smart00069
Location:25 → 85

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:87 → 123

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cl21584
Location:193 → 218

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_039094240.2 → XP_038950168.1 coagulation factor VII isoform X2

Conserved Domains (3) summary

smart00069
Location:25 → 85

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:87 → 123

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cl21584
Location:193 → 263

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...