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    F11 coagulation factor XI [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290757, updated on 4-Jan-2025

    Summary

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    Official Symbol
    F11provided by RGD
    Official Full Name
    coagulation factor XIprovided by RGD
    Primary source
    RGD:1309364
    See related
    EnsemblRapid:ENSRNOG00000013684 AllianceGenome:RGD:1309364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRGT00086
    Summary
    Enables serine-type aminopeptidase activity. Predicted to be involved in blood coagulation; plasminogen activation; and positive regulation of fibrinolysis. Predicted to act upstream of or within regulation of blood coagulation. Located in extracellular space. Human ortholog(s) of this gene implicated in factor XI deficiency and thrombosis. Orthologous to human F11 (coagulation factor XI). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 447.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See F11 in Genome Data Viewer
    Location:
    16q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (53720502..53741547)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (46987988..47009015)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (50179458..50201644)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1B, pseudogene 9 Neighboring gene kallikrein B1 Neighboring gene small ribosomal subunit protein eS26-like Neighboring gene melatonin receptor 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Noonan syndrome: partial factor XI deficiency. de Haan M, et al. Am J Med Genet, 1988 Feb. PMID 3354599
    2. A monoclonal antibody to high-molecular weight kininogen is therapeutic in a rodent model of reactive arthritis. Espinola RG, et al. Am J Pathol, 2004 Sep. PMID 15331420, Free PMC Article
    3. A novel mutation that leads to a congenital factor XI deficiency in a Japanese family. Sato E, et al. Am J Hematol, 2000 Apr. PMID 10706758
    4. Molecular genetic analysis of factor XI deficiency: identification of five novel gene alterations and the origin of type II mutation in Portuguese families. Ventura C, et al. Thromb Haemost, 2000 Nov. PMID 11127865
    5. High levels of coagulation factor XI as a risk factor for venous thrombosis. Meijers JC, et al. N Engl J Med, 2000 Mar 9. PMID 10706899

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coagulation factor XI
    NP_001398595.1
    XP_006253207.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411666.1 → NP_001398595.1  coagulation factor XI precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0G2K4I9
      Related
      ENSRNOP00000073061.3, ENSRNOT00000077662.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      53720502..53741547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253145.4 → XP_006253207.1  coagulation factor XI isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4I9
      Conserved Domains (4) summary
      smart00223
      Location:130 → 213
      APPLE; APPLE domain
      smart00020
      Location:317 → 545
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:318 → 545
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl00112
      Location:6 → 33
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047848.1: Suppressed sequence

      Description
      NM_001047848.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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