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    Osbp2 oxysterol binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305475, updated on 27-Dec-2024

    Summary

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    Symbol
    Osbp2provided by RGD
    Full Name
    oxysterol binding protein 2provided by RGD
    Primary source
    RGD:1310505
    See related
    EnsemblRapid:ENSRNOG00000019645 AllianceGenome:RGD:1310505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309479
    Summary
    Predicted to enable cholesterol binding activity. Predicted to be involved in lipid transport. Predicted to act upstream of or within spermatid development. Predicted to be located in acrosomal vesicle and apical dendrite. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Orthologous to human OSBP2 (oxysterol binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 164.5), Brain (RPKM 106.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Osbp2 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (82808693..82970386, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78585088..78746785, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (83943976..84107031, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene taurine up-regulated 1 Neighboring gene taurine up-regulated 1 Neighboring gene MORC family CW-type zinc finger 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134481865 Neighboring gene transcription initiation factor IIA subunit 2-like Neighboring gene high mobility group nucleosome binding domain 1 like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family. Udagawa O, et al. Genes Cells, 2014 Jan. PMID 24245814
    2. Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis. Loilome W, et al. Parasitol Int, 2012 Mar. PMID 21763455
    3. The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. Suchanek M, et al. Biochem J, 2007 Aug 1. PMID 17428193, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107232.2 → NP_001100702.1  oxysterol-binding protein 2

      See identical proteins and their annotated locations for NP_001100702.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AJ84, A6IKC8, D3ZHG4
      Conserved Domains (3) summary
      PHA03247
      Location:25 → 161
      PHA03247; large tegument protein UL36; Provisional
      cd13284
      Location:170 → 265
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:507 → 882
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      82808693..82970386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092013.2 → XP_038947941.1  oxysterol-binding protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZR95, A0A8I6AJ84
      Related
      ENSRNOP00000079573.1, ENSRNOT00000104902.2
      Conserved Domains (3) summary
      PHA03247
      Location:25 → 161
      PHA03247; large tegument protein UL36; Provisional
      cd13284
      Location:170 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:520 → 895
      Oxysterol_BP; Oxysterol-binding protein

    2. XM_039092014.2 → XP_038947942.1  oxysterol-binding protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6AJ84
      Conserved Domains (3) summary
      PHA03247
      Location:25 → 161
      PHA03247; large tegument protein UL36; Provisional
      cd13284
      Location:170 → 265
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:510 → 885
      Oxysterol_BP; Oxysterol-binding protein

    3. XM_063273188.1 → XP_063129258.1  oxysterol-binding protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AJ84
      Related
      ENSRNOP00000060468.4, ENSRNOT00000065501.4

    4. XM_039092010.2 → XP_038947938.1  oxysterol-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AJ84
      Conserved Domains (3) summary
      PHA03247
      Location:25 → 161
      PHA03247; large tegument protein UL36; Provisional
      cd13284
      Location:170 → 265
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:572 → 947
      Oxysterol_BP; Oxysterol-binding protein

    5. XM_039092012.2 → XP_038947940.1  oxysterol-binding protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AJ84
      Conserved Domains (3) summary
      PHA03247
      Location:25 → 161
      PHA03247; large tegument protein UL36; Provisional
      cd13284
      Location:170 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:523 → 898
      Oxysterol_BP; Oxysterol-binding protein

    6. XM_039092011.2 → XP_038947939.1  oxysterol-binding protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AJ84
      Conserved Domains (3) summary
      PHA03247
      Location:25 → 161
      PHA03247; large tegument protein UL36; Provisional
      cd13284
      Location:170 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:565 → 940
      Oxysterol_BP; Oxysterol-binding protein

    7. XM_039092009.2 → XP_038947937.1  oxysterol-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AJ84
      Conserved Domains (3) summary
      PHA03247
      Location:25 → 161
      PHA03247; large tegument protein UL36; Provisional
      cd13284
      Location:170 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:574 → 949
      Oxysterol_BP; Oxysterol-binding protein

    8. XM_039092008.2 → XP_038947936.1  oxysterol-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AJ84
      Conserved Domains (3) summary
      PHA03247
      Location:25 → 161
      PHA03247; large tegument protein UL36; Provisional
      cd13284
      Location:170 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:582 → 957
      Oxysterol_BP; Oxysterol-binding protein

    9. XM_039092007.2 → XP_038947935.1  oxysterol-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJ84
      Conserved Domains (3) summary
      PHA03247
      Location:25 → 161
      PHA03247; large tegument protein UL36; Provisional
      cd13284
      Location:170 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:585 → 960
      Oxysterol_BP; Oxysterol-binding protein

    10. XM_063273189.1 → XP_063129259.1  oxysterol-binding protein 2 isoform X10

    11. XM_063273197.1 → XP_063129267.1  oxysterol-binding protein 2 isoform X19

    12. XM_039092023.1 → XP_038947951.1  oxysterol-binding protein 2 isoform X12

      Conserved Domains (1) summary
      pfam01237
      Location:220 → 595
      Oxysterol_BP; Oxysterol-binding protein

    13. XM_063273190.1 → XP_063129260.1  oxysterol-binding protein 2 isoform X11

    14. XM_063273201.1 → XP_063129271.1  oxysterol-binding protein 2 isoform X25

    15. XM_063273191.1 → XP_063129261.1  oxysterol-binding protein 2 isoform X13

    16. XM_063273200.1 → XP_063129270.1  oxysterol-binding protein 2 isoform X23

    17. XM_063273198.1 → XP_063129268.1  oxysterol-binding protein 2 isoform X21

    18. XM_063273196.1 → XP_063129266.1  oxysterol-binding protein 2 isoform X17

    19. XM_063273202.1 → XP_063129272.1  oxysterol-binding protein 2 isoform X25

    20. XM_063273195.1 → XP_063129265.1  oxysterol-binding protein 2 isoform X12

    21. XM_063273194.1 → XP_063129264.1  oxysterol-binding protein 2 isoform X12

    22. XM_063273192.1 → XP_063129262.1  oxysterol-binding protein 2 isoform X15

    23. XM_063273193.1 → XP_063129263.1  oxysterol-binding protein 2 isoform X16

    24. XM_039092018.2 → XP_038947946.1  oxysterol-binding protein 2 isoform X14

      Conserved Domains (1) summary
      pfam01237
      Location:264 → 639
      Oxysterol_BP; Oxysterol-binding protein

    25. XM_039092016.1 → XP_038947944.1  oxysterol-binding protein 2 isoform X12

      Conserved Domains (1) summary
      pfam01237
      Location:220 → 595
      Oxysterol_BP; Oxysterol-binding protein

    26. XM_063273203.1 → XP_063129273.1  oxysterol-binding protein 2 isoform X27

    27. XM_039092024.1 → XP_038947952.1  oxysterol-binding protein 2 isoform X26

      Conserved Domains (1) summary
      pfam01237
      Location:150 → 525
      Oxysterol_BP; Oxysterol-binding protein

    28. XM_039092020.1 → XP_038947948.1  oxysterol-binding protein 2 isoform X20

      Conserved Domains (1) summary
      pfam01237
      Location:201 → 576
      Oxysterol_BP; Oxysterol-binding protein

    29. XM_039092019.1 → XP_038947947.1  oxysterol-binding protein 2 isoform X18

      Conserved Domains (1) summary
      pfam01237
      Location:212 → 587
      Oxysterol_BP; Oxysterol-binding protein

    30. XM_039092028.2 → XP_038947956.1  oxysterol-binding protein 2 isoform X30

      Conserved Domains (1) summary
      pfam01237
      Location:131 → 506
      Oxysterol_BP; Oxysterol-binding protein

    31. XM_039092031.2 → XP_038947959.1  oxysterol-binding protein 2 isoform X32

      Conserved Domains (1) summary
      pfam01237
      Location:111 → 486
      Oxysterol_BP; Oxysterol-binding protein

    32. XM_039092035.2 → XP_038947963.1  oxysterol-binding protein 2 isoform X34

      Conserved Domains (1) summary
      pfam01237
      Location:69 → 444
      Oxysterol_BP; Oxysterol-binding protein

    33. XM_039092034.2 → XP_038947962.1  oxysterol-binding protein 2 isoform X34

      Conserved Domains (1) summary
      pfam01237
      Location:69 → 444
      Oxysterol_BP; Oxysterol-binding protein

    34. XM_039092030.2 → XP_038947958.1  oxysterol-binding protein 2 isoform X32

      Conserved Domains (1) summary
      pfam01237
      Location:111 → 486
      Oxysterol_BP; Oxysterol-binding protein

    35. XM_039092029.2 → XP_038947957.1  oxysterol-binding protein 2 isoform X31

      Conserved Domains (1) summary
      pfam01237
      Location:120 → 495
      Oxysterol_BP; Oxysterol-binding protein

    36. XM_039092027.2 → XP_038947955.1  oxysterol-binding protein 2 isoform X30

      Conserved Domains (1) summary
      pfam01237
      Location:131 → 506
      Oxysterol_BP; Oxysterol-binding protein

    37. XM_039092025.2 → XP_038947953.1  oxysterol-binding protein 2 isoform X28

      Conserved Domains (1) summary
      pfam01237
      Location:142 → 517
      Oxysterol_BP; Oxysterol-binding protein

    38. XM_039092033.2 → XP_038947961.1  oxysterol-binding protein 2 isoform X33

      Conserved Domains (1) summary
      pfam01237
      Location:94 → 469
      Oxysterol_BP; Oxysterol-binding protein

    39. XM_039092026.2 → XP_038947954.1  oxysterol-binding protein 2 isoform X29

      Conserved Domains (1) summary
      pfam01237
      Location:136 → 511
      Oxysterol_BP; Oxysterol-binding protein

    40. XM_039092022.2 → XP_038947950.1  oxysterol-binding protein 2 isoform X24

      Conserved Domains (1) summary
      pfam01237
      Location:156 → 531
      Oxysterol_BP; Oxysterol-binding protein

    41. XM_039092021.2 → XP_038947949.1  oxysterol-binding protein 2 isoform X22

      Conserved Domains (2) summary
      PHA03247
      Location:25 → 161
      PHA03247; large tegument protein UL36; Provisional
      cd13284
      Location:170 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain

    RNA

    1. XR_005492966.2 RNA Sequence

    2. XR_005492968.2 RNA Sequence

    3. XR_005492963.2 RNA Sequence

    4. XR_005492965.2 RNA Sequence

    5. XR_005492962.2 RNA Sequence

    6. XR_005492969.2 RNA Sequence

    7. XR_005492964.2 RNA Sequence

    8. XR_010057367.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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