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    Snrnp35 small nuclear ribonucleoprotein U11/U12 subunit 35 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360803, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snrnp35provided by RGD
    Official Full Name
    small nuclear ribonucleoprotein U11/U12 subunit 35provided by RGD
    Primary source
    RGD:1310724
    See related
    EnsemblRapid:ENSRNOG00000001060 AllianceGenome:RGD:1310724
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    U1snrnpbp; RGD1310724
    Summary
    Predicted to enable mRNA binding activity and snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleolus. Predicted to be part of U12-type spliceosomal complex. Orthologous to human SNRNP35 (small nuclear ribonucleoprotein U11/U12 subunit 35). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 84.7), Muscle (RPKM 83.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snrnp35 in Genome Data Viewer
    Location:
    12q15
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (37773052..37781635, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32112032..32119829, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (37531082..37538823, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 2 Neighboring gene Rab interacting lysosomal protein-like 1 Neighboring gene Rab interacting lysosomal protein-like 2 Neighboring gene lysine methyltransferase 5A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Minor spliceosome components are predominantly localized in the nucleus. Pessa HK, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18559850, Free PMC Article
    2. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. Will CL, et al. RNA, 2004 Jun. PMID 15146077, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U12-type spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    U11/U12 small nuclear ribonucleoprotein 35 kDa protein
    Names
    U1 snRNP-binding protein homolog
    U11/U12 snRNP 35 kDa protein
    U11/U12 snRNP 35K
    small nuclear ribonucleoprotein 35 (U11/U12)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014127.1 → NP_001014149.1  U11/U12 small nuclear ribonucleoprotein 35 kDa protein

      See identical proteins and their annotated locations for NP_001014149.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086435
      UniProtKB/Swiss-Prot
      Q5U1W5
      Related
      ENSRNOP00000001402.4, ENSRNOT00000001402.9
      Conserved Domains (2) summary
      COG0724
      Location:41 → 126
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12237
      Location:48 → 137
      RRM_snRNP35; RNA recognition motif found in U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12-35K) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      37773052..37781635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249325.5 → XP_006249387.1  U11/U12 small nuclear ribonucleoprotein 35 kDa protein isoform X1

      See identical proteins and their annotated locations for XP_006249387.1

      UniProtKB/TrEMBL
      A6J0Z5, G3V639
      Related
      ENSRNOP00000083333.1, ENSRNOT00000096609.2
      Conserved Domains (1) summary
      cd12237
      Location:47 → 137
      RRM_snRNP35; RNA recognition motif (RRM) found in U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12-35K) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U1W5.1 GenPept UniProtKB/Swiss-Prot:Q5U1W5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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