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    Zcchc8 zinc finger CCHC-type containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288661, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zcchc8provided by RGD
    Official Full Name
    zinc finger CCHC-type containing 8provided by RGD
    Primary source
    RGD:1309774
    See related
    EnsemblRapid:ENSRNOG00000001243 AllianceGenome:RGD:1309774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA 3'-end processing. Predicted to be located in nuclear body. Predicted to be part of TRAMP complex and catalytic step 2 spliceosome. Orthologous to human ZCCHC8 (zinc finger CCHC-type containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 98.7), Spleen (RPKM 78.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zcchc8 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38530037..38553595)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32869170..32892707)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (38303665..38327174)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene kinetochore associated 1 Neighboring gene arginine and serine rich coiled-coil 2 Neighboring gene protein S100-A11-like Neighboring gene uncharacterized LOC134481295 Neighboring gene CAP-GLY domain containing linker protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation. Gable DL, et al. Genes Dev, 2019 Oct 1. PMID 31488579, Free PMC Article
    2. Interaction profiling identifies the human nuclear exosome targeting complex. Lubas M, et al. Mol Cell, 2011 Aug 19. PMID 21855801
    3. Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. Gustafson MP, et al. Biochem Biophys Res Commun, 2005 Dec 23. PMID 16263084
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TRAMP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCHC domain-containing protein 8
    Names
    zinc finger, CCHC domain containing 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400968.1 → NP_001387897.1  zinc finger CCHC domain-containing protein 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6GJE8, A6J135, D3ZUL8
      Related
      ENSRNOP00000001668.6, ENSRNOT00000001668.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      38530037..38553595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089238.2 → XP_038945166.1  zinc finger CCHC domain-containing protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZQ77
      Conserved Domains (1) summary
      cl02643
      Location:208 → 260
      PSP

    2. XM_006249334.5 → XP_006249396.1  zinc finger CCHC domain-containing protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZR78, A0A8I6GJE8
      Related
      ENSRNOP00000080646.1, ENSRNOT00000098796.2
      Conserved Domains (2) summary
      pfam00098
      Location:229 → 246
      zf-CCHC; Zinc knuckle
      cl02643
      Location:285 → 337
      PSP; PSP

    3. XM_063271178.1 → XP_063127248.1  zinc finger CCHC domain-containing protein 8 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZQ77

    4. XM_039089237.2 → XP_038945165.1  zinc finger CCHC domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASZ6, A0A8I6GJE8
      Related
      ENSRNOP00000095166.1, ENSRNOT00000108167.2
      Conserved Domains (2) summary
      pfam00098
      Location:204 → 221
      zf-CCHC; Zinc knuckle
      cl02643
      Location:260 → 312
      PSP

    5. XM_039089240.2 → XP_038945168.1  zinc finger CCHC domain-containing protein 8 isoform X5

      UniProtKB/TrEMBL
      A6J137
      Conserved Domains (2) summary
      pfam00098
      Location:42 → 59
      zf-CCHC; Zinc knuckle
      cl02643
      Location:98 → 150
      PSP

    6. XM_063271179.1 → XP_063127249.1  zinc finger CCHC domain-containing protein 8 isoform X5

      UniProtKB/TrEMBL
      A6J137

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105929.1: Suppressed sequence

      Description
      NM_001105929.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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