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    Aldh3b1 aldehyde dehydrogenase 3 family, member B1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309147, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Aldh3b1provided by RGD
    Official Full Name
    aldehyde dehydrogenase 3 family, member B1provided by RGD
    Primary source
    RGD:1359546
    See related
    EnsemblRapid:ENSRNOG00000017512 AllianceGenome:RGD:1359546
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in aldehyde metabolic process. Predicted to act upstream of or within aldehyde catabolic process and cellular response to oxidative stress. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ALDH3B1 (aldehyde dehydrogenase 3 family member B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 48.1), Lung (RPKM 41.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aldh3b1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210574545..210605188, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201145309..201162675, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219145457..219181536, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S8 Neighboring gene unc-93 homolog B1, TLR signaling regulator Neighboring gene aldehyde dehydrogenase 3 family, member B3 Neighboring gene aldehyde dehydrogenase 3 family, member B3-like, pseudogene 1 Neighboring gene aldehyde dehydrogenase 3 family, member B2, pseudogene 1 Neighboring gene aldehyde dehydrogenase 3 family, member B2 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family. Hsu LC, et al. Gene, 1994 Dec 30. PMID 7828891
    2. Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress. Marchitti SA, et al. Free Radic Biol Med, 2010 Nov 15. PMID 20699116, Free PMC Article
    3. Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification. Kitamura T, et al. Biochem J, 2015 Jan 1. PMID 25286108
    4. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. Kesimer M, et al. FASEB J, 2009 Jun. PMID 19190083, Free PMC Article
    5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95025

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-chloroallyl aldehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aldehyde dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables benzaldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables benzaldehyde dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty aldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty aldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aldehyde catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aldehyde metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aldehyde metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ethanol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde dehydrogenase family 3 member B1
    Names
    aldehyde dehydrogenase 7
    long-chain fatty aldehyde dehydrogenase
    medium-chain fatty aldehyde dehydrogenase
    NP_001006999.1
    XP_038935292.1
    XP_063120346.1
    XP_063120348.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006998.1 → NP_001006999.1  aldehyde dehydrogenase family 3 member B1

      See identical proteins and their annotated locations for NP_001006999.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083850
      UniProtKB/Swiss-Prot
      Q5XI42
      UniProtKB/TrEMBL
      A0A0G2K7W2
      Related
      ENSRNOP00000023789.5, ENSRNOT00000023789.7
      Conserved Domains (1) summary
      cd07132
      Location:5 → 447
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210574545..210605188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264278.1 → XP_063120348.1  aldehyde dehydrogenase family 3 member B1 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI42
      UniProtKB/TrEMBL
      A0A0G2K7W2
      Related
      ENSRNOP00000074371.3, ENSRNOT00000085312.3

    2. XM_063264276.1 → XP_063120346.1  aldehyde dehydrogenase family 3 member B1 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI42
      UniProtKB/TrEMBL
      A0A0G2K7W2

    3. XM_039079364.2 → XP_038935292.1  aldehyde dehydrogenase family 3 member B1 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI42
      UniProtKB/TrEMBL
      A0A0G2K7W2
      Conserved Domains (1) summary
      cd07132
      Location:5 → 447
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI42.1 GenPept UniProtKB/Swiss-Prot:Q5XI42

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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