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    Fbxo3 F-box protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 57443, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxo3provided by MGI
    Official Full Name
    F-box protein 3provided by MGI
    Primary source
    MGI:MGI:1929084
    See related
    Ensembl:ENSMUSG00000027180 AllianceGenome:MGI:1929084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fba; 1200002G09Rik; 1700026K02Rik
    Summary
    Enables ubiquitin-like ligase-substrate adaptor activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO3 (F-box protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 12.3), liver E14 (RPKM 12.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo3 in Genome Data Viewer
    Location:
    2 E2; 2 54.49 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103858144..103893582)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (104027799..104063237)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39896 Neighboring gene LIM domain only 2 Neighboring gene predicted gene, 38515 Neighboring gene RIKEN cDNA 4931422A03 gene Neighboring gene STARR-seq mESC enhancer starr_05277 Neighboring gene STARR-positive B cell enhancer ABC_E5954 Neighboring gene STARR-seq mESC enhancer starr_05279 Neighboring gene predicted gene, 24644 Neighboring gene CD59b antigen Neighboring gene STARR-seq mESC enhancer starr_05280 Neighboring gene CD59a antigen

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury. Gao Y, et al. Int J Mol Sci, 2022 Nov 7. PMID 36362432, Free PMC Article
    2. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Chen BB, et al. Nat Immunol, 2013 May. PMID 23542741, Free PMC Article
    3. FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis. Xu J, et al. PLoS Biol, 2023 Dec. PMID 38134227, Free PMC Article
    4. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. Ilyin GP, et al. Genomics, 2000 Jul 1. PMID 10945468
    5. FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator). Shao W, et al. J Biol Chem, 2016 Aug 19. PMID 27365398, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis.
      Title: FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis.
    2. E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury.
      Title: E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury.
    3. AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity.
      Title: FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 3
    Names
    F-box protein FBA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355504.1 → NP_001342433.1  F-box only protein 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' end compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BX640578
      Conserved Domains (2) summary
      smart00860
      Location:91 → 219
      SMI1_KNR4; SMI1 / KNR4 family
      cl01119
      Location:249 → 374
      DUF525; ApaG domain

    2. NM_001355505.1 → NP_001342434.1  F-box only protein 3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BX640578
      Related
      ENSMUSP00000106765.2, ENSMUST00000111135.8
      Conserved Domains (3) summary
      smart00860
      Location:121 → 249
      SMI1_KNR4; SMI1 / KNR4 family
      pfam12937
      Location:13 → 57
      F-box-like; F-box-like
      cl01119
      Location:279 → 404
      DUF525; ApaG domain

    3. NM_001355506.1 → NP_001342435.1  F-box only protein 3 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' end and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BX640578
      Conserved Domains (2) summary
      smart00860
      Location:91 → 219
      SMI1_KNR4; SMI1 / KNR4 family
      cl01119
      Location:249 → 374
      DUF525; ApaG domain

    4. NM_001355507.1 → NP_001342436.1  F-box only protein 3 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK085686, BX640578
      Consensus CDS
      CCDS89529.1
      UniProtKB/TrEMBL
      A2BHN6
      Related
      ENSMUSP00000106766.2, ENSMUST00000111136.8
      Conserved Domains (3) summary
      smart00860
      Location:121 → 249
      SMI1_KNR4; SMI1 / KNR4 family
      pfam12937
      Location:13 → 57
      F-box-like
      cl01119
      Location:279 → 358
      DUF525; ApaG domain

    5. NM_020593.2 → NP_065618.1  F-box only protein 3 isoform 2

      See identical proteins and their annotated locations for NP_065618.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF233226, AK006392, BY105498
      Consensus CDS
      CCDS16485.1
      UniProtKB/Swiss-Prot
      Q9DC63
      UniProtKB/TrEMBL
      Q9CVV6
      Related
      ENSMUSP00000099625.4, ENSMUST00000102565.4
      Conserved Domains (3) summary
      pfam09346
      Location:121 → 249
      SMI1_KNR4; SMI1 / KNR4 family (SUKH-1)
      pfam12937
      Location:13 → 57
      F-box-like; F-box-like
      cl01119
      Location:279 → 404
      DUF525; Protein of unknown function (DUF525)

    6. NM_212433.1 → NP_997598.1  F-box only protein 3 isoform 1

      See identical proteins and their annotated locations for NP_997598.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK029594, AK049870, BB470024, BE980708, BY105498
      Consensus CDS
      CCDS16484.1
      UniProtKB/Swiss-Prot
      A2BHN5, A2BHN7, Q3TKB0, Q3U9C1, Q8C7I0, Q8CEJ0, Q91VI9, Q9D2J5, Q9DC63, Q9JIE4
      Related
      ENSMUSP00000028603.4, ENSMUST00000028603.10
      Conserved Domains (3) summary
      pfam09346
      Location:121 → 249
      SMI1_KNR4; SMI1 / KNR4 family (SUKH-1)
      pfam12937
      Location:13 → 57
      F-box-like; F-box-like
      cl01119
      Location:279 → 404
      DUF525; Protein of unknown function (DUF525)

    RNA

    1. NR_149726.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an alternate internal exon and differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK150097, BX640578
      Related
      ENSMUST00000143799.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      103858144..103893582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DC63.1 GenPept UniProtKB/Swiss-Prot:Q9DC63

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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