Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Smarca4provided by MGI
Official Full Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4provided by MGI
Primary source: MGI:MGI:88192
See related: Ensembl:ENSMUSG00000032187 AllianceGenome:MGI:88192
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Brg1; BAF190A; SW1/SNF; HP1-BP72; SNF2beta; b2b692Clo; b2b508.1Clo
Summary: Enables several functions, including ATP hydrolysis activity; DNA polymerase binding activity; and nucleic acid binding activity. Involved in nervous system development; positive regulation of Wnt signaling pathway; and positive regulation of metabolic process. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including blastocyst development; circulatory system development; and erythrocyte differentiation. Located in euchromatin; male germ cell nucleus; and perichromatin fibrils. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study breast cancer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; hepatocellular carcinoma; lung non-small cell carcinoma; and rhabdoid tumor predisposition syndrome 2. Orthologous to human SMARCA4 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 48.7), CNS E14 (RPKM 45.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.84 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (21527377..21615526)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (21616106..21704230)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Age-related decline in the expression of BRG1, ATM and ATR are partially reversed by dietary restriction in the livers of female mice.
Title: Age-related decline in the expression of BRG1, ATM and ATR are partially reversed by dietary restriction in the livers of female mice.
Enhancer switching in cell lineage priming is linked to eRNA, Brg1's AT-hook, and SWI/SNF recruitment.
Title: Enhancer switching in cell lineage priming is linked to eRNA, Brg1's AT-hook, and SWI/SNF recruitment.
Acute depletion of BRG1 reveals its primary function as an activator of transcription.
Title: Acute depletion of BRG1 reveals its primary function as an activator of transcription.
Epicardial SMARCA4 deletion exacerbates cardiac injury in myocardial infarction and is related to the inhibition of epicardial epithelial-mesenchymal transition.
Title: Epicardial SMARCA4 deletion exacerbates cardiac injury in myocardial infarction and is related to the inhibition of epicardial epithelial-mesenchymal transition.
BRG1 programs PRC2-complex repression and controls oligodendrocyte differentiation and remyelination.
Title: BRG1 programs PRC2-complex repression and controls oligodendrocyte differentiation and remyelination.
SMARCA4 Loss and Mutated beta-Catenin Induce Proliferative Lesions in the Murine Embryonic Cerebellum.
Title: SMARCA4 Loss and Mutated β-Catenin Induce Proliferative Lesions in the Murine Embryonic Cerebellum.
SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions.
Title: SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions.
Ablation of Brg1 in fibroblast/myofibroblast lineages attenuates renal fibrosis in mice with diabetic nephropathy.
Title: Ablation of Brg1 in fibroblast/myofibroblast lineages attenuates renal fibrosis in mice with diabetic nephropathy.
BRG1 accelerates mesothelial cell senescence and peritoneal fibrosis by inhibiting mitophagy through repression of OXR1.
Title: BRG1 accelerates mesothelial cell senescence and peritoneal fibrosis by inhibiting mitophagy through repression of OXR1.
The chromatin remodeling protein BRG1 mediates Ang II induced pro-fibrogenic response in renal fibroblasts.
Title: The chromatin remodeling protein BRG1 mediates Ang II induced pro-fibrogenic response in renal fibroblasts.

Submit: New GeneRIF Correction See all GeneRIFs (177)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (5) 1 citation
Endonuclease-mediated (5) 1 citation
Spontaneous (1) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Smarca4 (e-PCR), detects polymorphism
- UniSTS:547367

Smarca4 (e-PCR), detects polymorphism
- UniSTS:265811

Smarca4 (e-PCR), detects polymorphism
- UniSTS:516567

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP hydrolysis activity	TAS Traceable Author Statement more info	PubMed
enables ATP-dependent activity, acting on DNA	ISO Inferred from Sequence Orthology more info
enables ATP-dependent chromatin remodeler activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA polymerase binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables Tat protein binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables lncRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables lysine-acetylated histone binding	ISO Inferred from Sequence Orthology more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables nucleosome array spacer activity	IBA Inferred from Biological aspect of Ancestor more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within aortic smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blastocyst growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blastocyst hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within definitive erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic hindlimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epidermis morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_negative_effect gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glial cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart trabecula formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens fiber cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nucleosome assembly	TAS Traceable Author Statement more info	PubMed
involved_in nucleosome disassembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pharyngeal arch artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA binding	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of glucose mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within primitive erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G0 to G1 transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic metaphase/anaphase transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of nucleotide-excision repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular septum development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of GBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of RSC-type complex	NAS Non-traceable Author Statement more info	PubMed
part_of SWI/SNF complex	IDA Inferred from Direct Assay more info	PubMed
part_of SWI/SNF complex	ISO Inferred from Sequence Orthology more info
part_of SWI/SNF complex	NAS Non-traceable Author Statement more info	PubMed
part_of SWI/SNF complex	TAS Traceable Author Statement more info	PubMed
part_of SWI/SNF superfamily-type complex	IDA Inferred from Direct Assay more info	PubMed
part_of bBAF complex	NAS Non-traceable Author Statement more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	NAS Non-traceable Author Statement more info	PubMed
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in kinetochore	NAS Non-traceable Author Statement more info	PubMed
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of nBAF complex	IDA Inferred from Direct Assay more info	PubMed
part_of nBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of npBAF complex	IDA Inferred from Direct Assay more info	PubMed
part_of npBAF complex	ISO Inferred from Sequence Orthology more info
part_of npBAF complex	NAS Non-traceable Author Statement more info	PubMed
located_in nuclear matrix	NAS Non-traceable Author Statement more info	PubMed
NOT located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perichromatin fibrils	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription activator BRG1

Names: ATP-dependent helicase SMARCA4; BRG1-associated factor 190A; SNF2-beta; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; protein brahma homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001174078.1 → NP_001167549.1 transcription activator BRG1 isoform 1

See identical proteins and their annotated locations for NP_001167549.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4.

Source sequence(s)

AK160825, BC079560

Consensus CDS

CCDS52737.1

UniProtKB/TrEMBL

A0A0R4J170

Related

ENSMUSP00000096547.4, ENSMUST00000098948.10

Conserved Domains (9) summary

cd05516
Location:1428 → 1534

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 570

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 217

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07529
Location:461 → 531

HSA

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1291 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex
NM_001174079.1 → NP_001167550.1 transcription activator BRG1 isoform 3

See identical proteins and their annotated locations for NP_001167550.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 4.

Source sequence(s)

AK160825, AK166837, BC079560

Consensus CDS

CCDS57662.1

UniProtKB/Swiss-Prot

Q3TKT4, Q3TUD7, Q6AXG8

Related

ENSMUSP00000133922.2, ENSMUST00000174008.8

Conserved Domains (9) summary

cd05516
Location:1425 → 1530

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 570

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 217

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07529
Location:461 → 531

HSA

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1291 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex
NM_001357764.1 → NP_001344693.1 transcription activator BRG1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).

Source sequence(s)

AC161371

Conserved Domains (9) summary

cd05516
Location:1458 → 1564

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 570

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 217

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07529
Location:461 → 531

HSA

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1324 → 1389

SnAC; Snf2-ATP coupling, chromatin remodelling complex
NM_011417.3 → NP_035547.2 transcription activator BRG1 isoform 2

See identical proteins and their annotated locations for NP_035547.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4..

Source sequence(s)

AK160825, BC079560

Consensus CDS

CCDS22909.1

UniProtKB/Swiss-Prot

Q3TKT4

Related

ENSMUSP00000034707.9, ENSMUST00000034707.15

Conserved Domains (9) summary

cd05516
Location:1425 → 1531

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 570

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 217

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07529
Location:461 → 531

HSA

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1291 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

21527377..21615526

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242438.3 → XP_011240740.1 transcription activator BRG1 isoform X1

See identical proteins and their annotated locations for XP_011240740.1

Conserved Domains (9) summary

cd05516
Location:1461 → 1567

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 570

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 217

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07529
Location:461 → 531

HSA

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1324 → 1389

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_011242434.1 → XP_011240736.1 transcription activator BRG1 isoform X1

See identical proteins and their annotated locations for XP_011240736.1

Conserved Domains (9) summary

cd05516
Location:1461 → 1567

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 570

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 217

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07529
Location:461 → 531

HSA

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1324 → 1389

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_011242435.1 → XP_011240737.1 transcription activator BRG1 isoform X2

Conserved Domains (9) summary

cd05516
Location:1461 → 1566

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 570

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 217

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07529
Location:461 → 531

HSA

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1324 → 1389

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_006510122.2 → XP_006510185.2 transcription activator BRG1 isoform X3

See identical proteins and their annotated locations for XP_006510185.2

Conserved Domains (9) summary

cd05516
Location:1458 → 1564

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 570

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 217

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07529
Location:461 → 531

HSA

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1324 → 1389

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_011242436.1 → XP_011240738.1 transcription activator BRG1 isoform X4

Conserved Domains (9) summary

cd05516
Location:1458 → 1563

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 570

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 217

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07529
Location:461 → 531

HSA

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1324 → 1389

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_006510117.2 → XP_006510180.2 transcription activator BRG1 isoform X6

See identical proteins and their annotated locations for XP_006510180.2

UniProtKB/TrEMBL

A0A0R4J170

Conserved Domains (9) summary

cd05516
Location:1428 → 1534

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 570

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 217

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07529
Location:461 → 531

HSA

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1291 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_006510119.2 → XP_006510182.2 transcription activator BRG1 isoform X7

See identical proteins and their annotated locations for XP_006510182.2

UniProtKB/Swiss-Prot

Q3TKT4

Conserved Domains (9) summary

cd05516
Location:1425 → 1531

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 570

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 217

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07529
Location:461 → 531

HSA

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1291 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_006510120.2 → XP_006510183.2 transcription activator BRG1 isoform X8

See identical proteins and their annotated locations for XP_006510183.2

UniProtKB/Swiss-Prot

Q3TKT4, Q3TUD7, Q6AXG8

Conserved Domains (9) summary

cd05516
Location:1425 → 1530

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 570

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 217

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07529
Location:461 → 531

HSA

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1291 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_011242437.4 → XP_011240739.1 transcription activator BRG1 isoform X5

Conserved Domains (9) summary

cd05516
Location:1481 → 1587

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:632 → 676

BRK; domain in transcription and CHROMO domain helicases

PLN03142
Location:770 → 1252

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:390 → 590

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:62 → 237

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:751 → 1001

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07529
Location:481 → 551

HSA

pfam08880
Location:191 → 225

QLQ

pfam14619
Location:1344 → 1409

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_030244151.1 → XP_030100011.1 transcription activator BRG1 isoform X9

UniProtKB/TrEMBL

Q3UI73

Conserved Domains (4) summary

cd05516
Location:713 → 819

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

PLN03142
Location:2 → 484

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

cd17996
Location:3 → 233

DEXHc_SMARCA2_SMARCA4; DEXH-box helicase domain of SMARCA2 and SMARCA4

pfam14619
Location:576 → 641

SnAC; Snf2-ATP coupling, chromatin remodelling complex