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    Agfg2 ArfGAP with FG repeats 2 [ Mus musculus (house mouse) ]

    Gene ID: 231801, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Agfg2provided by MGI
    Official Full Name
    ArfGAP with FG repeats 2provided by MGI
    Primary source
    MGI:MGI:2443267
    See related
    Ensembl:ENSMUSG00000029722 AllianceGenome:MGI:2443267
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hrbl; RABR; RAB-R; A630095P14Rik
    Summary
    This gene encodes a paralog of the HIV-1 Rev binding proteins that serve as cellular co-factors for HIV-1 Rev protein in shuttling viral pre-mRNAs from the nucleus to the cytoplasm. The encoded protein contains an ADP-ribosylation factor GTPase activating protein (Arf-GAP) zinc finger domain, several phenylalanine-glycine (FG) motifs and asparagine-proline-phenylalanine (NPF) motifs. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in thymus adult (RPKM 56.4), adrenal adult (RPKM 28.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Agfg2 in Genome Data Viewer
    Location:
    5 G2; 5 76.59 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137648725..137683068, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137650463..137684806, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20605 Neighboring gene sin3 associated polypeptide Neighboring gene insulin receptor substrate 3 Neighboring gene STARR-positive B cell enhancer ABC_E236 Neighboring gene predicted gene 15498 Neighboring gene predicted gene, 54308 Neighboring gene Sp110 nuclear body protein, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Organization patterns of the AGFG genes: an evolutionary study. Panaro MA, et al. Immunopharmacol Immunotoxicol, 2011 Mar. PMID 21284487
    2. Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization. Coda L, et al. J Biol Chem, 1998 Jan 30. PMID 9446614
    3. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. Wong KA, et al. PLoS One, 2012. PMID 22558309, Free PMC Article
    4. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7148, MGC61203

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid nucleus differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP domain and FG repeat-containing protein 2
    Names
    HIV-1 Rev-binding protein-like protein
    arf-GAP domain and FG repeats-containing protein 2
    rev/Rex activation domain-binding protein related

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303266.1 → NP_001290195.1  arf-GAP domain and FG repeat-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001290195.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an additional in-frame exon in the 3' coding region, compared to variant 2. The resulting protein (isoform 3) is longer than isoform 2.
      Source sequence(s)
      AC124730
      Consensus CDS
      CCDS80443.1
      UniProtKB/TrEMBL
      Q3TBU7, Q3U2K8
      Related
      ENSMUSP00000098112.5, ENSMUST00000100544.11
      Conserved Domains (1) summary
      cl02464
      Location:40 → 152
      ArfGap; Putative GTPase activating protein for Arf

    2. NM_001303271.1 → NP_001290200.1  arf-GAP domain and FG repeat-containing protein 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site and contains an additional in-frame exon in the 3' coding region, compared to variant 2. The resulting protein (isoform 4) is longer than isoform 2.
      Source sequence(s)
      AC124730
      UniProtKB/TrEMBL
      Q3TBU7
      Related
      ENSMUSP00000117351.2, ENSMUST00000151839.2
      Conserved Domains (1) summary
      cl02464
      Location:40 → 152
      ArfGap; Putative GTPase activating protein for Arf

    3. NM_178162.3 → NP_835456.1  arf-GAP domain and FG repeat-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_835456.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the shortest isoform (2).
      Source sequence(s)
      AC124730, BC046788
      Consensus CDS
      CCDS19774.1
      UniProtKB/Swiss-Prot
      Q80WC7, Q8BKS5, Q99J67
      UniProtKB/TrEMBL
      Q3TBU7
      Related
      ENSMUSP00000031736.10, ENSMUST00000031736.16
      Conserved Domains (1) summary
      cl02464
      Location:40 → 152
      ArfGap; Putative GTPase activating protein for Arf

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137648725..137683068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504570.3 → XP_006504633.1  arf-GAP domain and FG repeat-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      Q3TBU7
      Conserved Domains (2) summary
      PHA03247
      Location:163 → 411
      PHA03247; large tegument protein UL36; Provisional
      cd17903
      Location:30 → 146
      ArfGap_AGFG2; ArfGAP domain of AGFG2 (ArfGAP domain and FG repeat-containing protein 2)

    2. XM_006504569.3 → XP_006504632.1  arf-GAP domain and FG repeat-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      Q3TBU7
      Conserved Domains (2) summary
      PHA03247
      Location:146 → 453
      PHA03247; large tegument protein UL36; Provisional
      cd17903
      Location:30 → 146
      ArfGap_AGFG2; ArfGAP domain of AGFG2 (ArfGAP domain and FG repeat-containing protein 2)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145566.1: Suppressed sequence

      Description
      NM_145566.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80WC7.1 GenPept UniProtKB/Swiss-Prot:Q80WC7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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