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    TLE5 TLE family member 5, transcriptional modulator [ Bos taurus (domestic cattle) ]

    Gene ID: 505375, updated on 27-Dec-2024

    Summary

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    Gene symbol
    TLE5
    Gene description
    TLE family member 5, transcriptional modulator
    See related
    Ensembl:ENSBTAG00000031363
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    AES
    Orthologs
    human mouse all
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    Genomic context

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    See TLE5 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (20735348..20743588)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha 15 Neighboring gene transfer RNA methionine (anticodon CAU) Neighboring gene G protein subunit alpha 11 Neighboring gene uncharacterized LOC112447372 Neighboring gene TLE family member 2, transcriptional corepressor Neighboring gene TLE family member 6, subcortical maternal complex member Neighboring gene zinc finger protein 77

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TLE family member 5
    Names
    amino-terminal enhancer of split

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128497.2 → NP_001121969.1  TLE family member 5

      See identical proteins and their annotated locations for NP_001121969.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103327
      UniProtKB/TrEMBL
      A0A3Q1MIW3, F1MP44, Q3SYY6
      Related
      ENSBTAP00000079736.1, ENSBTAT00000112132.1
      Conserved Domains (1) summary
      pfam03920
      Location:11 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      20735348..20743588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024993937.2 → XP_024849705.1  TLE family member 5 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MHW0, A0A3Q1MIW3
      Related
      ENSBTAP00000068702.1, ENSBTAT00000079511.2
      Conserved Domains (1) summary
      pfam03920
      Location:2 → 124
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials