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    LEAP2 liver enriched antimicrobial peptide 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 282270, updated on 27-Dec-2024

    Summary

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    Official Symbol
    LEAP2provided by VGNC
    Official Full Name
    liver enriched antimicrobial peptide 2provided by VGNC
    Primary source
    VGNC:VGNC:30831
    See related
    BGD:BT28765
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    LEAP-2
    Orthologs
    human mouse all
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    Genomic context

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    See LEAP2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (44453424..44454342)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 9 Neighboring gene ubiquinol-cytochrome c reductase complex III subunit VII Neighboring gene ALF transcription elongation factor 4 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver. Krause A, et al. Protein Sci, 2003 Jan. PMID 12493837, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC133595

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    liver-expressed antimicrobial peptide 2
    Names
    liver expressed antimicrobial peptide 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174559.4 → NP_776984.1  liver-expressed antimicrobial peptide 2 precursor

      See identical proteins and their annotated locations for NP_776984.1

      Status: PROVISIONAL

      Source sequence(s)
      BC108204
      UniProtKB/Swiss-Prot
      Q32P98, Q95JC3
      Conserved Domains (1) summary
      pfam07359
      Location:1 → 77
      LEAP-2; Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      44453424..44454342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95JC3.1 GenPept UniProtKB/Swiss-Prot:Q95JC3

    Gene LinkOut

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