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    DEGS1 delta 4-desaturase, sphingolipid 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 507290, updated on 27-Dec-2024

    Summary

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    Official Symbol
    DEGS1provided by VGNC
    Official Full Name
    delta 4-desaturase, sphingolipid 1provided by VGNC
    Primary source
    VGNC:VGNC:27990
    See related
    BGD:BT14860; Ensembl:ENSBTAG00000012705
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    DES1
    Orthologs
    human mouse all
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    Genomic context

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    See DEGS1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (27363456..27373731)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene tumor protein p53 binding protein 2 Neighboring gene F-box protein 28 Neighboring gene nuclear VCP like Neighboring gene large ribosomal subunit protein P1-like Neighboring gene uncharacterized LOC101905510

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128422

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables sphingolipid delta-4 desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sphingolipid delta(4)-desaturase DES1
    Names
    degenerative spermatocyte homolog 1, lipid desaturase
    dihydroceramide desaturase-1
    retinol isomerase
    NP_001029461.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034289.2 → NP_001029461.1  sphingolipid delta(4)-desaturase DES1

      See identical proteins and their annotated locations for NP_001029461.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103031
      UniProtKB/Swiss-Prot
      Q3ZBY7
      Related
      ENSBTAP00000016887.5, ENSBTAT00000016887.5
      Conserved Domains (2) summary
      cd03508
      Location:26 → 315
      Delta4-sphingolipid-FADS-like; The Delta4-sphingolipid Fatty Acid Desaturase (Delta4-sphingolipid-FADS)-like CD includes the integral-membrane enzymes, dihydroceramide Delta-4 desaturase, involved in the synthesis of sphingosine; and the human membrane fatty acid (lipid) desaturase ...
      pfam08557
      Location:6 → 40
      Lipid_DES; Sphingolipid Delta4-desaturase (DES)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27363456..27373731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZBY7.1 GenPept UniProtKB/Swiss-Prot:Q3ZBY7

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