YARS1 tyrosyl-tRNA synthetase 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: YARS1provided by VGNC
Official Full Name: tyrosyl-tRNA synthetase 1provided by VGNC
Primary source: VGNC:VGNC:37015
See related: BGD:BT19865; Ensembl:ENSBTAG00000018065
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: YARS; tyrS
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	2	NC_037329.1 (120849176..120881197)

Chromosome 2 - NC_037329.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

conformational transition of Trp144 from buried native state into highly relaxing polar solvent environment
Title: Conformational flexibility of cytokine-like C-module of tyrosyl-tRNA synthetase monitored by Trp144 intrinsic fluorescence.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables tRNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables tyrosine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in tyrosyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tyrosine--tRNA ligase, cytoplasmic

Names: tyrRS; tyrosyl--tRNA ligase; tyrosyl-tRNA synthetase, cytoplasmic

NP_776645.1

EC 6.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174220.2 → NP_776645.1 tyrosine--tRNA ligase, cytoplasmic

See identical proteins and their annotated locations for NP_776645.1

Status: PROVISIONAL

Source sequence(s)

AF087021

UniProtKB/Swiss-Prot

Q29465, Q9TSJ1

UniProtKB/TrEMBL

Q0III5

Related

ENSBTAP00000024051.3, ENSBTAT00000024051.4

Conserved Domains (4) summary

cd02799
Location:363 → 468

tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...

TIGR00234
Location:9 → 328

tyrS; tyrosyl-tRNA synthetase

TIGR00399
Location:345 → 467

metG_C_term; methionyl-tRNA synthetase C-terminal region/beta chain

cl00015
Location:8 → 328

nt_trans; nucleotidyl transferase superfamily