U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CTSB cathepsin B [ Bos taurus (domestic cattle) ]

    Gene ID: 281105, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CTSBprovided by VGNC
    Official Full Name
    cathepsin Bprovided by VGNC
    Primary source
    VGNC:VGNC:27813
    See related
    BGD:BT10007; Ensembl:ENSBTAG00000012442
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CATB
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CTSB in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (7566167..7587042)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene defensin beta 134 Neighboring gene defensin beta 136 Neighboring gene farnesyl-diphosphate farnesyltransferase 1 Neighboring gene nei like DNA glycosylase 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex. Yamamoto A, et al. J Biochem, 2000 Apr. PMID 10739956
    2. Expression of lysosomal cathepsin B during calf myoblast-myotube differentiation. Characterization of a cDNA encoding bovine cathepsin B. Béchet DM, et al. J Biol Chem, 1991 Jul 25. PMID 1856234
    3. Disulfide bridges of bovine spleen cathepsin B. Baudys M, et al. Biol Chem Hoppe Seyler, 1990 Jun. PMID 2390214
    4. Identification of the second (buried) cysteine residue and of the C-terminal disulfide bridge of bovine spleen cathepsin B. Baudys M, et al. Biol Chem Hoppe Seyler, 1988 May. PMID 3144290
    5. Amino acid sequence of bovine spleen cathepsin B. Meloun B, et al. J Biol Chem, 1988 Jul 5. PMID 3379063

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cathepsin B deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
      Title: Cathepsins S, B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer's disease.
    2. The peptides, all of which contain a C-terminal free acid, were tested as inactivators of bovine cathepsin B, in an attempt at exploiting the known and, amongst the cysteine proteinases, unique carboxy dipeptidyl peptidase activity of the protease.
      Title: The inactivation of bovine cathepsin B by novel N-chloro-acetyl-dipeptides: application of the Houghten 'tea bag' methodology to inhibitor synthesis.
    3. evidence shows cathepsin B activity may not be redox regulated; however, the stability of the enzyme at neutral pH is dependent on redox potential, and on the presence of oxidising agents.
      Title: Cathepsin B stability, but not activity, is affected in cysteine:cystine redox buffers.
    4. Overexpressing cathepsin B reduced the Vascular Endothelial Growth Factor-dependent tube response
      Title: Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    cathepsin B
    Names
    BCSB
    NP_776456.1
    XP_005209879.1
    XP_059744925.1
    XP_059744926.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174031.2 → NP_776456.1  cathepsin B precursor

      See identical proteins and their annotated locations for NP_776456.1

      Status: PROVISIONAL

      Source sequence(s)
      L06075
      UniProtKB/Swiss-Prot
      P07688, Q3ZC03
      UniProtKB/TrEMBL
      A0AAA9TG45
      Related
      ENSBTAP00000036650.4, ENSBTAT00000036795.6
      Conserved Domains (2) summary
      cd02620
      Location:81 → 328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:26 → 65
      Propeptide_C1; Peptidase family C1 propeptide

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      7566167..7587042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059888942.1 → XP_059744925.1  cathepsin B isoform X1

      UniProtKB/Swiss-Prot
      P07688, Q3ZC03
      UniProtKB/TrEMBL
      A0AAA9TG45

    2. XM_005209822.5 → XP_005209879.1  cathepsin B isoform X1

      See identical proteins and their annotated locations for XP_005209879.1

      UniProtKB/Swiss-Prot
      P07688, Q3ZC03
      UniProtKB/TrEMBL
      A0AAA9TG45
      Conserved Domains (2) summary
      cd02620
      Location:81 → 328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:26 → 65
      Propeptide_C1; Peptidase family C1 propeptide

    3. XM_059888943.1 → XP_059744926.1  cathepsin B isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07688.5 GenPept UniProtKB/Swiss-Prot:P07688

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.