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    MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 522002, updated on 1-Jan-2025

    Summary

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    Official Symbol
    MAP4K1provided by VGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:31204
    See related
    Ensembl:ENSBTAG00000021145
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MAP4K1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (48365445..48382105, complement)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene RAS guanyl releasing protein 4 Neighboring gene ryanodine receptor 1 Neighboring gene microRNA mir-2329-2 Neighboring gene microRNA mir-2329-1 Neighboring gene eukaryotic translation initiation factor 3 subunit K Neighboring gene actinin alpha 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables MAP kinase kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 1
    NP_001069293.2
    XP_024834039.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075825.2 → NP_001069293.2  mitogen-activated protein kinase kinase kinase kinase 1

      See identical proteins and their annotated locations for NP_001069293.2

      Status: PROVISIONAL

      Source sequence(s)
      BC149646, BT026208
      UniProtKB/TrEMBL
      E1BH31
      Related
      ENSBTAP00000028180.6, ENSBTAT00000028180.7
      Conserved Domains (3) summary
      smart00036
      Location:499 → 806
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:17 → 274
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06613
      Location:16 → 274
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      48365445..48382105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024978271.2 → XP_024834039.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform X1

      UniProtKB/TrEMBL
      E1BH31
      Conserved Domains (2) summary
      smart00036
      Location:499 → 807
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:16 → 274
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    Nucleotide Protein Strain
    Heading Accession and Version

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