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    GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [ Bos taurus (domestic cattle) ]

    Gene ID: 281183, updated on 27-Dec-2024

    Summary

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    Official Symbol
    GARTprovided by VGNC
    Official Full Name
    phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetaseprovided by VGNC
    Primary source
    VGNC:VGNC:29255
    See related
    BGD:BT23672; Ensembl:ENSBTAG00000009188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See GART in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (1985253..2012391)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene DNA replication fork stabilization factor DONSON Neighboring gene SON DNA and RNA binding protein Neighboring gene microRNA mir-6501 Neighboring gene uncharacterized LOC104970777 Neighboring gene DnaJ heat shock protein family (Hsp40) member C28

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Detection of haplotypes associated with prenatal death in dairy cattle and identification of deleterious mutations in GART, SHBG and SLC37A2. Fritz S, et al. PLoS One, 2013. PMID 23762392, Free PMC Article
    2. Molecular characterization and chromosomal assignment of the bovine glycinamide ribonucleotide formyltransferase (GART) gene on cattle chromosome 1q12.1-q12.2. Wöhlke A, et al. Gene, 2005 Mar 28. PMID 15777723
    3. Mapping of the bovine genes of the de novo AMP synthesis pathway. Bønsdorff T, et al. Anim Genet, 2004 Dec. PMID 15566465
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Three novel mutations with very damaging effect on the protein structure, according to SIFT and Polyphen-2, were detected in GART, SHBG and SLC37A2 genes.
      Title: Detection of haplotypes associated with prenatal death in dairy cattle and identification of deleterious mutations in GART, SHBG and SLC37A2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137968

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphoribosylamine-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphoribosylglycinamide formyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adenine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trifunctional purine biosynthetic protein adenosine-3
    Names
    glycinamide ribonucleotide synthetase
    phosphoribosylglycinamide synthetase
    NP_001035563.1
    XP_059741795.1
    XP_059741826.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040473.2 → NP_001035563.1  trifunctional purine biosynthetic protein adenosine-3

      See identical proteins and their annotated locations for NP_001035563.1

      Status: PROVISIONAL

      Source sequence(s)
      BC122573
      UniProtKB/Swiss-Prot
      Q59A32
      UniProtKB/TrEMBL
      A0AAA9SDW8
      Related
      ENSBTAP00000012108.3, ENSBTAT00000012108.5
      Conserved Domains (7) summary
      cd02196
      Location:469 → 767
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      cd08645
      Location:809 → 991
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK00885
      Location:4 → 427
      PRK00885; phosphoribosylamine--glycine ligase; Provisional
      PRK05385
      Location:435 → 766
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
      pfam01071
      Location:105 → 298
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:334 → 424
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4 → 104
      GARS_N; Phosphoribosylglycinamide synthetase, N domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      1985253..2012391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059885812.1 → XP_059741795.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

      UniProtKB/Swiss-Prot
      Q59A32
      UniProtKB/TrEMBL
      A0AAA9SDW8

    2. XM_059885843.1 → XP_059741826.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

      UniProtKB/Swiss-Prot
      Q59A32
      UniProtKB/TrEMBL
      A0AAA9SDW8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q59A32.1 GenPept UniProtKB/Swiss-Prot:Q59A32

    Gene LinkOut

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