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    NTRK1 neurotrophic receptor tyrosine kinase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 353111, updated on 1-Jan-2025

    Summary

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    Official Symbol
    NTRK1provided by VGNC
    Official Full Name
    neurotrophic receptor tyrosine kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:32309
    See related
    BGD:BT20495; Ensembl:ENSBTAG00000003060
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    TRKA
    Orthologs
    human mouse all
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    Genomic context

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    See NTRK1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (13971638..13989990, complement)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104971464 Neighboring gene leucine rich repeat containing 71 Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene insulin receptor related receptor Neighboring gene SH2 domain containing 2A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Direct effects of nerve growth factor on thecal cells from antral ovarian follicles. Dissen GA, et al. Endocrinology, 2000 Dec. PMID 11108289
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neurotrophin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neurotrophin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high affinity nerve growth factor receptor
    Names
    neurotrophic tyrosine kinase, receptor, type 1
    XP_002686012.2
    XP_024845697.1
    XP_024845698.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      13971638..13989990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024989929.2 → XP_024845697.1  high affinity nerve growth factor receptor isoform X2

      UniProtKB/TrEMBL
      F1MC14
      Related
      ENSBTAP00000071315.2, ENSBTAT00000067057.2
      Conserved Domains (6) summary
      cd04971
      Location:299 → 379
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:195 → 282
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05092
      Location:497 → 776
      PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A
      sd00031
      Location:68 → 92
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:92 → 150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:151 → 192
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    2. XM_002685966.7 → XP_002686012.2  high affinity nerve growth factor receptor isoform X1

      See identical proteins and their annotated locations for XP_002686012.2

      UniProtKB/TrEMBL
      F1MC14
      Related
      ENSBTAP00000003980.6, ENSBTAT00000003980.6
      Conserved Domains (8) summary
      cd04971
      Location:299 → 379
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:195 → 282
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00221
      Location:509 → 780
      STYKc; Protein kinase; unclassified specificity
      pfam07679
      Location:194 → 282
      I-set; Immunoglobulin I-set domain
      cd05092
      Location:503 → 782
      PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A
      sd00031
      Location:68 → 92
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:92 → 150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:151 → 192
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    3. XM_024989930.2 → XP_024845698.1  high affinity nerve growth factor receptor isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MJ18
      Conserved Domains (3) summary
      cd04971
      Location:163 → 243
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:59 → 146
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05092
      Location:367 → 646
      PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A
    Nucleotide Protein Strain
    Heading Accession and Version

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